Millipore Sigma Vibrant Logo

506155 Pifithrin-μ - CAS 64984-31-2 - Calbiochem

Pifithrin-μ, CAS 64984-31-2, is a cell-permeable inhibitor of p53 interaction with Bcl-xL & Bcl-2. Inhibits p53 translocation to mitochondria without affecting the transactivation function of p53.

Pifithrin-μ - CAS 64984-31-2 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Phenylacetylenylsulfonamide, Hsp70 Inhibitor I

Primary Target: p53 interaction with Bcl-xL and Bcl-2 proteins
View Products on Sigmaaldrich.com
506155
Visualizza prezzi e disponibilità

Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
64984-31-2C₈H₇NO₂S

Prezzi e disponibilità

Numero di catalogo DisponibilitàConfezionamento Qtà/conf Prezzo Quantità
506155-10MG
Verifica della disponibilità in corso...
—
Disponibilità limitata Disponibilità limitata
A magazzino 
Fuori produzione
Disponibili quantità limitate
La disponibilità deve essere confermata
    Prodotti rimanenti: riceverà un nostro avviso
      Prodotti rimanenti: riceverà un nostro avviso
      Will advise
      Contatti il Servizio Clienti
      Contact Customer Service

      		 Fiala di plastica 10 mg
      Ricerca del prezzo in corso...
      Non è stato possibile trovare il prezzo
      La quantità minima deve essere un multiplo di
      Maximum Quantity is
      Al termine dell'ordine Maggiori informazioni
      Lei ha salvato ()
       
      —
      Richiedi il prezzo
      		 —
      Description
      OverviewA cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Effectively protects against γ radiation-induced cell death in vitro and animal lethality in vivo. Because Pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53, it is superior to Pifithrin-α (Cat. No. 506132) in in vivo studies. Shown to selectively interact with inducible HSP70 and disrupt its functions.
      Catalogue Number506155
      Brand Family Calbiochem®
      SynonymsPhenylacetylenylsulfonamide, Hsp70 Inhibitor I
      References
      ReferencesLeu, J., et al. 2009. Mol. Cell 36, 15.
      Strom, E., et al. 2006. Nat. Chem. Biol. 2, 474.
      Product Information
      CAS number64984-31-2
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₈H₇NO₂S
      Chemical formulaC₈H₇NO₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationPifithrin-μ, CAS 64984-31-2, is a cell-permeable inhibitor of p53 interaction with Bcl-xL & Bcl-2. Inhibits p53 translocation to mitochondria without affecting the transactivation function of p53.
      Biological Information
      Primary Targetp53 interaction with Bcl-xL and Bcl-2 proteins
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      506155-10MG 04055977272253

      Documentation

      Pifithrin-μ - CAS 64984-31-2 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Pifithrin-μ - CAS 64984-31-2 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      506155

      Riferimenti bibliografici

      Panoramica delle referenze
      Leu, J., et al. 2009. Mol. Cell 36, 15.
      Strom, E., et al. 2006. Nat. Chem. Biol. 2, 474.

      Brochure

      Titolo
      p53 And Related Products
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-October-2009 RFH
      SynonymsPhenylacetylenylsulfonamide, Hsp70 Inhibitor I
      DescriptionA cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Effectively protects against γ radiation-induced cell death in vitro and animal lethality in vivo. Because Pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53, it is superior to Pifithrin-α (Cat. No. 506132) in in vivo studies. Shown to selectively interact with inducible HSP70 and disrupt its functions.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number64984-31-2
      Chemical formulaC₈H₇NO₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLeu, J., et al. 2009. Mol. Cell 36, 15.
      Strom, E., et al. 2006. Nat. Chem. Biol. 2, 474.