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513030 PD 169316 - CAS 152121-53-4 - Calbiochem

A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM).

PD 169316 - CAS 152121-53-4 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole

Primary Target: p38 MAP kinase
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Tabella delle specifiche principali

CAS #Empirical Formula
152121-53-4C₂₀H₁₃FN₄O₂

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      Description
      OverviewA potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC50 = 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.
      Catalogue Number513030
      Brand Family Calbiochem®
      Synonyms4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole
      References
      ReferencesNath, R., et al. 2001. Cell Mol. Biol. Lett. 6, 173.
      Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
      Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.
      Product Information
      CAS number152121-53-4
      ATP CompetitiveY
      FormOrange-yellow solid
      Hill FormulaC₂₀H₁₃FN₄O₂
      Chemical formulaC₂₀H₁₃FN₄O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetp38 MAP kinase
      Primary Target IC<sub>50</sub>89 nM against p38 MAP kinase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      513030-1MG 04055977198621

      Documentation

      PD 169316 - CAS 152121-53-4 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      PD 169316 - CAS 152121-53-4 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      513030

      Riferimenti bibliografici

      Panoramica delle referenze
      Nath, R., et al. 2001. Cell Mol. Biol. Lett. 6, 173.
      Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
      Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-January-2010 RFH
      Synonyms4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole
      DescriptionA potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC50= 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.
      FormOrange-yellow solid
      CAS number152121-53-4
      Chemical formulaC₂₀H₁₃FN₄O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesNath, R., et al. 2001. Cell Mol. Biol. Lett. 6, 173.
      Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
      Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.