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234490 PD 153035 - CAS 153436-54-5 - Calbiochem

An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC₅₀ = 25 pM; Ki = 6 pM).

PD 153035 - CAS 153436-54-5 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: AG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32

Primary Target: EGFR
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234490
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Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
153436-54-5C₁₆H₁₄BrN₃O₂

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234490-1MG
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      Description
      OverviewAn extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234491) in DMSO is also available.
      Catalogue Number234490
      Brand Family Calbiochem®
      SynonymsAG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32
      References
      ReferencesBridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
      Fry, D.W., et al. 1994. Science 265, 1093.
      Product Information
      CAS number153436-54-5
      ATP CompetitiveY
      DeclarationSold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
      FormWhite solid
      Hill FormulaC₁₆H₁₄BrN₃O₂
      Chemical formulaC₁₆H₁₄BrN₃O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEGFR
      Primary Target IC<sub>50</sub>25 pM
      Primary Target K<sub>i</sub>6 pM against epidermal growth factor receptor (EGFR)
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      234490-1MG 04055977200256

      Documentation

      PD 153035 - CAS 153436-54-5 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      PD 153035 - CAS 153436-54-5 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      234490

      Riferimenti bibliografici

      Panoramica delle referenze
      Bridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
      Fry, D.W., et al. 1994. Science 265, 1093.

      Brochure

      Titolo
      An Introduction to Inhibitors and Their Biological Applications - 1st Edition

      Informazioni tecniche

      Titolo
      JAK/STAT Signaling Research Focus

      Posters

      Titolo
      Human Kinome & InhibitorSelect™ Libraries

      Citazioni

      Titolo
    • Nikolay L. Malinin, et al. (2005) Amyloid-b neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity. Proceedings of the National Academy of Sciences (USA) 102, 3058-3063.
      		•
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      SynonymsAG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32
      DescriptionAn extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.
      FormWhite solid
      CAS number153436-54-5
      Chemical formulaC₁₆H₁₄BrN₃O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesBridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
      Fry, D.W., et al. 1994. Science 265, 1093.
      Citation
    • Nikolay L. Malinin, et al. (2005) Amyloid-b neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity. Proceedings of the National Academy of Sciences (USA) 102, 3058-3063.
      		•