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509267 Opn4 Antagonist - CAS 457961-34-1 - Calbiochem

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509267
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CAS #Empirical Formula
457961-34-1C₁₃H₁₉NO₃S

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5092670001
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      Description
      OverviewA sulfonamide compound that prevents melanopsin/Opn4 photoactivation in a reversible and cis-Retinal-competitive manner without apparent affinity toward bovine retina rhodopsin or a panel of 74 other receptors, ion channels, and enzymes. Effectively inhibits cellular phototransduction mediated by human Opn4 (IC50 = 665 nM; using CHO transfectants), murine Opn4 (IC50 = 190 nM; using transfected Xenopus oocytes), and rat Opn4 (10 µM; using primary rat ipRGCs). Shown to effectively suppress PLR (pupillary light reflex; pupil constriction) in a time- and Opn4-dependent manner in mice (30 mg/kg i.p.) in vivo. Likewise, blue light insensitivity is observed in Opn4-/- and AA92593-treated wild-type, but not vehicle-treated wild-type, P14 neonatal mice.
      Catalogue Number509267
      Brand Family Calbiochem®
      SynonymsOpn4 Antagonist, Opsinamide, Melanopsin-inhibiting Sulfonamide AA92593, Melanopsin Antagonist, Opsinamide AA92593, 1-(4-Methoxy-3-methyl-benzenesulfonyl)piperidine, 1-(4-Methoxy-3-methylphenylsulfonyl)piperidine
      References
      ReferencesJones, K.A., et al. 2013. Nat. Chem. Biol. 9, 630.
      Product Information
      CAS number457961-34-1
      FormWhite solid
      Hill FormulaC₁₃H₁₉NO₃S
      Chemical formulaC₁₃H₁₉NO₃S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetmelanopsin (Opn4)
      Primary Target K<sub>i</sub>110 and 160 nM for human and mouse melanopsin, respectively)
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 monthst at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Numero di catalogo GTIN
      5092670001 04055977241747