480065 Sigma-AldrichNecrostatin-1 - CAS 4311-88-0 - Calbiochem
Necrostatin-1, CAS 4311-88-0, is a cell-permeable, potent, and selective blocker of necroptosis (EC₅₀ = 494 nM in FADD-deficient Jurkat cells treated with TNF-α).
More>> Necrostatin-1, CAS 4311-88-0, is a cell-permeable, potent, and selective blocker of necroptosis (EC₅₀ = 494 nM in FADD-deficient Jurkat cells treated with TNF-α). Less<<Sinonimi: Necrosome Inhibitor I, 5-(Indol-3-ylmethyl)-(2-thio-3-methyl)hydantoin, Nec-1, Necrosis Inhibitor II, Nec1, RIP1 Inhibitor I, Methyl-thiohydantoin-tryptophan, MTH-Trp, Receptor-Interacting Protein 1 Inhibitor I, RIPK 1 Inhibitor I
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Panoramica
Tabella delle specifiche principali
CAS # | Empirical Formula |
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4311-88-0 | C₁₃H₁₃N₃OS |
Prezzi e disponibilità
Numero di catalogo | Disponibilità | Confezionamento | Qtà/conf | Prezzo | Quantità | |
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480065-5MG |
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Fiala di plastica | 5 mg |
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Description | |
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Overview | A cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain injury. Exhibits no effect on DR-induced apoptosis. Also acts as a selective and ATP-competitive inhibitor of RIP1 kinase with negligible effect of RIP2 kinase activity. Nec-1 target appears to be a critical common necroptotic step upstream of execution events and downstream of DRs. Inactive control, Nec-1i, is also available (Cat. No. 480066). Also available as a 25 mM solution in DMSO (Cat. No. 505224). |
Catalogue Number | 480065 |
Brand Family | Calbiochem® |
Synonyms | Necrosome Inhibitor I, 5-(Indol-3-ylmethyl)-(2-thio-3-methyl)hydantoin, Nec-1, Necrosis Inhibitor II, Nec1, RIP1 Inhibitor I, Methyl-thiohydantoin-tryptophan, MTH-Trp, Receptor-Interacting Protein 1 Inhibitor I, RIPK 1 Inhibitor I |
Product Information | |
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CAS number | 4311-88-0 |
ATP Competitive | Y |
Form | Yellow crystalline solid |
Hill Formula | C₁₃H₁₃N₃OS |
Chemical formula | C₁₃H₁₃N₃OS |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | Blocker of necroptosis |
Primary Target IC<sub>50</sub> | EC50 = 494 nM in blocking necrosis in FADD-deficient Jurkat cells treated with TNF-α |
Purity | ≥95% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Numero di catalogo | GTIN |
480065-5MG | 04055977201871 |