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480418 NF279 - CAS 202983-32-2 - Calbiochem

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480418
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CAS #Empirical Formula
202983-32-2C₄₉H₃₀N₆O₂₃S₆ · 6Na

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      Description
      OverviewA suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB ~ 1 µM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no effect on α1A adrenoceptors, adenosine A1 and A2B receptors, histamine H1, muscarinic M3 and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X1 >P2X2 >P2X3 >P2X4 (IC50 = 19 nM, 770 nM, 1.62 µM and >300 µM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X1 > human P2X1 > > rat P2X2 > rat P2X3 ~ human P2X7 > > human P2X4. Not degraded by ecto-nucleotidases.
      Catalogue Number480418
      Brand Family Calbiochem®
      Synonyms8,8ʹ-(Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid, Na
      References
      ReferencesKlapperstück, M., et al. 2000. Eur. J. Pharmacol. 387, 245.
      Rettinger, J., et al. 2000. Neuropharmacol. 39, 2044.
      Lambrecht, G., et al. 1999. Prog. Brain Res. 120,107.
      Damer, S., et al. 1998. Eur. J. Pharmacol. 350, R5.
      Product Information
      CAS number202983-32-2
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₄₉H₃₀N₆O₂₃S₆ · 6Na
      Chemical formulaC₄₉H₃₀N₆O₂₃S₆ · 6Na
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetP2X receptor
      Primary Target IC<sub>50</sub>~ 1 µM as antagonist of P2X receptor in smooth muscle; 19 nM, 770 nM, 1.62 µM and <300 µM, against P2X1, P2X2, P2X3, P2X4, respectively, in Xenopus oocytes pre-incubated with ATP
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Numero di catalogo GTIN
      480418-5MG 04055977201352