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14-578M NEK6 Protein, active, 250 µg

Active, N-terminal His6-tagged, recombinant, human NEK6, amino acids 2 -end, for use in Kinase Assays.

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14-578M
250 µg  Also available in 10 μg size (cat#14-578) and in bulk (cat# 14-578-K).
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      Replacement Information
      Description
      Catalogue Number14-578M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionNEK6 Protein, active, 250 µg
      OverviewNN-terminal His6-tagged, recombinant, human NEK6, amino acids 2 - end
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal His6-tagged, recombinant, human NEK6, amino acids 2 -end, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThe Aspergillus nidulans 'never in mitosis A' (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform functions similar to those of NIMA.[supplied by OMIM]
      Gene Symbol
      • NEK6
      • SID6-1512
      Protein TargetNEK6
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyMisc
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9HC98 # Activated during M phase. Required for chromosome segregation at metaphase-anaphase transition and therefore for mitotic progression. Inhibition of activity results in apoptosis.
      COFACTOR: Magnesium.
      SIZE: 313 amino acids; 35714 Da
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
      TISSUE SPECIFICITY: Ubiquitous, with highest expression in heart and skeletal muscle.
      PTM: Autophosphorylated.
      SIMILARITY: SwissProt: Q9HC98 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. NIMA subfamily. & Contains 1 protein kinase domain.
      Molecular Weight40.5kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of FLAKSFGSPNRAYKK
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-578) and in bulk (cat# 14-578-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      14-578M 04053252580741

      Documentation