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445888 Metastin (45-54) - Calbiochem

Metastin (45-54), CAS 374675-21-5, is a decapeptide that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors).

Metastin (45-54) - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: KiSS-1 (112-121), Kisspeptin-10, H-YNWNSFGLRF-NH₂

Primary Target: AXOR12 and hOT7T175
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445888
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₆₃H₈₃N₁₇O₁₄

Prezzi e disponibilità

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445888-1MG
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      Description
      OverviewA decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors). Induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (Ki = 42 pM) compared to Metastin (Cat. No. 445885).
      Catalogue Number445888
      Brand Family Calbiochem®
      SynonymsKiSS-1 (112-121), Kisspeptin-10, H-YNWNSFGLRF-NH₂
      References
      ReferencesKotani, M., et al. 2001. J. Biol. Chem. 276, 34631.
      Ohtaki, T., et al. 2001. Nature 411, 613.
      Muir, A.I., et al. 2001. J. Biol. Chem. 276, 28969.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₆₃H₈₃N₁₇O₁₄
      Chemical formulaC₆₃H₈₃N₁₇O₁₄
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      ApplicationMetastin (45-54), CAS 374675-21-5, is a decapeptide that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors).
      Biological Information
      Primary TargetAXOR12 and hOT7T175
      Primary Target K<sub>i</sub>42 pM for AXOR12 and hOT7T175
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      445888-1MG 04055977204636

      Documentation

      Metastin (45-54) - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Metastin (45-54) - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      445888

      Riferimenti bibliografici

      Panoramica delle referenze
      Kotani, M., et al. 2001. J. Biol. Chem. 276, 34631.
      Ohtaki, T., et al. 2001. Nature 411, 613.
      Muir, A.I., et al. 2001. J. Biol. Chem. 276, 28969.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-August-2008 RFH
      SynonymsKiSS-1 (112-121), Kisspeptin-10, H-YNWNSFGLRF-NH₂
      DescriptionA decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptor). More potent than the parent peptide. Induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (Ki = 42 pM, determined by competitive binding analysis) as compared to Metastin (Cat. No. 444885).
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₆₃H₈₃N₁₇O₁₄
      Peptide SequenceH-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesKotani, M., et al. 2001. J. Biol. Chem. 276, 34631.
      Ohtaki, T., et al. 2001. Nature 411, 613.
      Muir, A.I., et al. 2001. J. Biol. Chem. 276, 28969.