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444800 Meloxicam - CAS 71125-38-7 - Calbiochem

A cell-permeable, non-steroidal anti-inflammatory drug (NSAID) of the oxicam family which preferentially inhibits the inducible isoform of COX-2 (IC₅₀ = 4.7 µM) relative to COX-1 (IC₅₀ = 36.6 µM).

Meloxicam - CAS 71125-38-7 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 4-Hydroxy-2-methyl-N-(5-methyl-2-thiazoyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide

Primary Target: COX-2
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Tabella delle specifiche principali

CAS #Empirical Formula
71125-38-7C₁₄H₁₃N₃O₄S₂

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444800-100MG
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      Description
      OverviewA cell-permeable, non-steroidal anti-inflammatory drug (NSAID) of the oxicam family which preferentially inhibits the inducible isoform of COX-2 (IC50 = 4.7 µM) relative to COX-1 (IC50 = 36.6 µM). Also inhibits the growth of colorectal cancer cells in vitro.
      Catalogue Number444800
      Brand Family Calbiochem®
      Synonyms4-Hydroxy-2-methyl-N-(5-methyl-2-thiazoyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
      References
      ReferencesBlanco, F.J., et al. 1999. J. Rheumatol. 26, 1366.
      Davies, N.M., and Skjodt, N.M. 1999. Clin. Pharmacokinet. 36, 115.
      Goldman, A.P., et al. 1998. Carcinogenesis 19, 2195.
      Product Information
      CAS number71125-38-7
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₄H₁₃N₃O₄S₂
      Chemical formulaC₁₄H₁₃N₃O₄S₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCOX-2
      Primary Target IC<sub>50</sub>4.7 µM, 36.6 µM against the inducible isoform of COX-2 relative to COX-1, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      444800-100MG 04055977186147

      Documentation

      Meloxicam - CAS 71125-38-7 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Meloxicam - CAS 71125-38-7 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      444800

      Riferimenti bibliografici

      Panoramica delle referenze
      Blanco, F.J., et al. 1999. J. Rheumatol. 26, 1366.
      Davies, N.M., and Skjodt, N.M. 1999. Clin. Pharmacokinet. 36, 115.
      Goldman, A.P., et al. 1998. Carcinogenesis 19, 2195.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-May-2008 RFH
      Synonyms4-Hydroxy-2-methyl-N-(5-methyl-2-thiazoyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
      DescriptionA cell-permeable, non-steroidal, anti-inflammatory drug (NSAID) of the oxicam family that preferentially inhibits the inducible isoform of cyclooxygenase-2 (COX-2; IC50 = 4.7 µM) relative to cyclooxygenase-1 (COX-1; IC50 = 36.6 µM). Also inhibits the growth of colorectal cancer cells in vitro.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number71125-38-7
      Chemical formulaC₁₄H₁₃N₃O₄S₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 5826
      ReferencesBlanco, F.J., et al. 1999. J. Rheumatol. 26, 1366.
      Davies, N.M., and Skjodt, N.M. 1999. Clin. Pharmacokinet. 36, 115.
      Goldman, A.P., et al. 1998. Carcinogenesis 19, 2195.