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444250 MMP Inhibitor I - Calbiochem

MMP Inhibitor I, CAS 124168-73-6, is an inhibitor of multiple MMPs (IC50 = 1.0, 1.0, 150, and 30 M for MMP-1, MMP-8, MMP-3, and MMP-9, respectively).

MMP Inhibitor I - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: FN-439

Primary Target: MMP-1, MMP-8
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444250
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Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₂₃H₃₄N₆O₆

Prezzi e disponibilità

Numero di catalogo DisponibilitàConfezionamento Qtà/conf Prezzo Quantità
444250-10MG
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      Description
      OverviewA tetrapeptidyl hydroxamic acid that inhibits MMP-1 and MMP-8 (IC50 = 1.0 µM), MMP-9 (IC50 = 30 µM) and MMP-3 (IC50 = 150 µM). Retains its activity even after prolonged incubation with PRONASE® Protease (Cat. Nos. 53702 or 537088) or human granulocyte elastase.
      Catalogue Number444250
      Brand Family Calbiochem®
      SynonymsFN-439
      References
      ReferencesHagemamn, T., et al. 2004. Carcinogenesis 25, 1543.
      Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₃H₃₄N₆O₆
      Chemical formulaC₂₃H₃₄N₆O₆
      ReversibleN
      Quality LevelMQ100
      Applications
      ApplicationMMP Inhibitor I, CAS 124168-73-6, is an inhibitor of multiple MMPs (IC50 = 1.0, 1.0, 150, and 30 M for MMP-1, MMP-8, MMP-3, and MMP-9, respectively).
      Biological Information
      Primary TargetMMP-1, MMP-8
      Primary Target IC<sub>50</sub>1 µM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide Sequence4-Abz-Gly-Pro-D-Leu-D-Ala-NH-OH [Abz = aminobenzoyl]
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      444250-10MG 04055977186505

      Documentation

      MMP Inhibitor I - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      MMP Inhibitor I - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      444250

      Riferimenti bibliografici

      Panoramica delle referenze
      Hagemamn, T., et al. 2004. Carcinogenesis 25, 1543.
      Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.

      Citazioni

      Titolo
    • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
      		•
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-October-2024 JSW
      SynonymsFN-439
      DescriptionA tetrapeptidyl hydroxamic acid that inhibits interstitial and granulocyte collagenases (MMP-1 and MMP-8; IC50 = 1 µM), granulocyte gelatinase (MMP-9; IC50 = 30 µM), adn skin fibroblast stromelysin (MMP-3; IC50 = 150 µM). Retains its activity even after prolonged incubation with PRONASE® Protease (Cat. No. 53702) or human neutrophil elastase.
      FormWhite solid
      Chemical formulaC₂₃H₃₄N₆O₆
      Peptide Sequence4-Abz-Gly-Pro-D-Leu-D-Ala-NH-OH [Abz = aminobenzoyl]
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesHagemamn, T., et al. 2004. Carcinogenesis 25, 1543.
      Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.
      Citation
    • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
      		•