480073 Sigma-AldrichMLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem
MLKL Inhibitor, Necrosulfonamide, CAS 432531-71-0, is a cell-permeable inhibitor that covalently modifies Cys88 and blocks human MLKL adaptor function.
More>> MLKL Inhibitor, Necrosulfonamide, CAS 432531-71-0, is a cell-permeable inhibitor that covalently modifies Cys88 and blocks human MLKL adaptor function. Less<<MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Sinonimi: (E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide, Mixed Lineage Kinase Domain-Like Protein Inhibitor, Necrosome Inhibitor II, Necrosulfonamide, Necrosis Inhibitor III
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Prezzi e disponibilità
| Numero di catalogo | Disponibilità | Confezionamento | Qtà/conf | Prezzo | Quantità | |
|---|---|---|---|---|---|---|
| 480073-25MG |
|
Bottiglia di vetro | 25 mg |
|
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| Description | |
|---|---|
| Overview | A cell-permeable acrylamide compound that inhibits human, but not murine, MLKL adaptor function via covalent modification of Cys86 and is more potent than Nec-1 (Cat. No. 480065) in preventing necrotic/necroptotic death in human HT-29 (IC50 = 124 nM and 2 µM, respectively), being ineffective against necrosis/necroptosis in murine L929 or apoptosis in human RIP3-null Panc-1 cells. Unlike Nec-1, which prevents necrosome formation by blocking RIP1-RIP3 interaction, MLKL prevents the MLKL-RIP1-RIP3 necrosome complex from interacting with further downstream effectors. |
| Catalogue Number | 480073 |
| Brand Family | Calbiochem® |
| Synonyms | (E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide, Mixed Lineage Kinase Domain-Like Protein Inhibitor, Necrosome Inhibitor II, Necrosulfonamide, Necrosis Inhibitor III |
| References | |
|---|---|
| References | Dunai, Z.A., et al. 2012. PLoS One 7, e41945. Sun, L., et al. 2012. Cell 148, 213. |
| Product Information | |
|---|---|
| CAS number | 432531-71-0 |
| Form | Dark yellow solid |
| Hill Formula | C₁₈H₁₅N₅O₆S₂ |
| Chemical formula | C₁₈H₁₅N₅O₆S₂ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | human MLKL |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Numero di catalogo | GTIN |
| 480073-25MG | 04055977201895 |