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475874 MK571, Sodium Salt - CAS 115104-28-4 - Calbiochem

A selective, competitive antagonist of leukotriene D4 (LTD4) (Ki = 2.1 nM for inhibition of [³H]LTD4 binding to human lung membranes).

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: L 660711, Sodium Salt, (E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic Acid, Sodium Salt

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Tabella delle specifiche principali

CAS #Empirical Formula
115104-28-4C₂₆H₂₆ClN₂O₃S₂ • Na

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      Description
      OverviewA selective, competitive antagonist of leukotriene D4 (LTD4) (Ki = 2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes). Also inhibits multidrug resistance-associated protein 1 (MRP1).
      Catalogue Number475874
      Brand Family Calbiochem®
      SynonymsL 660711, Sodium Salt, (E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic Acid, Sodium Salt
      References
      ReferencesOlson, D.P., et al. 2001. Cytometry 46, 105.
      Van der Kolk, D.M., et al. 1998. Clin. Cancer Res. 4, 1727.
      Jones, T.R., et al. 1989. Can. J. Physiol. Pharmacol. 67, 17.
      Product Information
      CAS number115104-28-4
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₆H₂₆ClN₂O₃S₂ • Na
      Chemical formulaC₂₆H₂₆ClN₂O₃S₂ • Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAntagonist of leukotriene D4 (LTD4)
      Primary Target K<sub>i</sub>2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions in are stable for up to 1 week at -20°C; DMSO stock solutions are stable for up to 6 months at -20°C. Acidic pH and heavy metals will accelerate decomposition.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      475874-5MG 07790788050474

      Documentation

      MK571, Sodium Salt - CAS 115104-28-4 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      MK571, Sodium Salt - CAS 115104-28-4 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      475874

      Riferimenti bibliografici

      Panoramica delle referenze
      Olson, D.P., et al. 2001. Cytometry 46, 105.
      Van der Kolk, D.M., et al. 1998. Clin. Cancer Res. 4, 1727.
      Jones, T.R., et al. 1989. Can. J. Physiol. Pharmacol. 67, 17.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-August-2008 RFH
      SynonymsL 660711, Sodium Salt, (E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic Acid, Sodium Salt
      DescriptionA selective, competitive antagonist of leukotriene D4 (LTD4) receptor (Ki = 2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes). Also reported to inhibit multidrug resistance-associated protein 1 (MRP1).
      FormOff-white solid
      CAS number115104-28-4
      Chemical formulaC₂₆H₂₆ClN₂O₃S₂ • Na
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityH₂O (200 mg/ml) or DMSO (10 mg/ml)
      Storage Protect from moisture
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions in are stable for up to 1 week at -20°C; DMSO stock solutions are stable for up to 6 months at -20°C. Acidic pH and heavy metals will accelerate decomposition.
      Toxicity Standard Handling
      ReferencesOlson, D.P., et al. 2001. Cytometry 46, 105.
      Van der Kolk, D.M., et al. 1998. Clin. Cancer Res. 4, 1727.
      Jones, T.R., et al. 1989. Can. J. Physiol. Pharmacol. 67, 17.