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434610 Leukadherin-1 - CAS 344897-95-6 - Calbiochem

A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B.

Leukadherin-1 - CAS 344897-95-6 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid, LA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, αMβ2 Agonist II, CD11b Agonist II

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434610
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Tabella delle specifiche principali

CAS #Empirical Formula
344897-95-6C₂₂H₁₅NO₄S₂

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434610-25MG
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      Description
      OverviewA furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 (Cat. No. 407271) in enhancing Mac-1-mediated cell adhesion (EC50 = 4 vs. >50 µM on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models involving mice, rats, and zebrafish embryos in vivo.
      Catalogue Number434610
      Brand Family Calbiochem®
      Synonyms4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid, LA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, αMβ2 Agonist II, CD11b Agonist II
      References
      ReferencesMaiguel, D., et al. 2011. Sci. Signal. 4, ra57.
      Product Information
      CAS number344897-95-6
      FormRed-brown solid
      Hill FormulaC₂₂H₁₅NO₄S₂
      Chemical formulaC₂₂H₁₅NO₄S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      434610-25MG 04055977210217

      Documentation

      Leukadherin-1 - CAS 344897-95-6 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Leukadherin-1 - CAS 344897-95-6 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      434610

      Riferimenti bibliografici

      Panoramica delle referenze
      Maiguel, D., et al. 2011. Sci. Signal. 4, ra57.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-May-2012 JSW
      Synonyms4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid, LA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, αMβ2 Agonist II, CD11b Agonist II
      DescriptionA furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 (Cat. No. 407271) in enhancing Mac-1-mediated cell adhesion (EC50 = 4 vs. >50 µM on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models in vivo, including thioglycolate-induced peritonitis (10 nmol/0.2 ml/mouse; i.v.), anti-GBM-induced nephritis (25 nmol/0.5 ml/mouse; i.p.), balloon-induced artery injury (50 nmol/1 ml/rat; i.m.), and zebrafish tailfin injury.CR3
      FormRed-brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number344897-95-6
      Chemical formulaC₂₂H₁₅NO₄S₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml; yellow solution)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesMaiguel, D., et al. 2011. Sci. Signal. 4, ra57.