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422708 KN-93 - CAS 139298-40-1 - Calbiochem

KN-93, CAS 139298-40-1, is a cell-permeable, reversible and competitive inhibitor of CaM kinase II (Ki = 370 nM). Binds to the CaM binding site and prevents the association of CaM with CaMKII.

KN-93 - CAS 139298-40-1 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine)

Primary Target: cam kinase 2
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Tabella delle specifiche principali

CAS #Empirical Formula
139298-40-1C₂₆H₂₉CIN₂O₄S

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          Description
          OverviewA cell-permeable, reversible and competitive inhibitor of rat brain CaM kinase II (Ki = 370 nM). Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effects on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH/3T3 cells. A 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422712) in DMSO is also available.
          Catalogue Number422708
          Brand Family Calbiochem®
          Synonyms2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine)
          References
          ReferencesFan, G.H., et al. 1999. Mol. Pharmacol. 56, 39.
          Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
          Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
          Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
          Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
          Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
          Product Information
          CAS number139298-40-1
          ATP CompetitiveY
          FormOff-white solid
          Hill FormulaC₂₆H₂₉CIN₂O₄S
          Chemical formulaC₂₆H₂₉CIN₂O₄S
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationKN-93, CAS 139298-40-1, is a cell-permeable, reversible and competitive inhibitor of CaM kinase II (Ki = 370 nM). Binds to the CaM binding site and prevents the association of CaM with CaMKII.
          Biological Information
          Primary Targetcam kinase 2
          Primary Target K<sub>i</sub>370 nM against rat brain CaM kinase II
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Numero di catalogo GTIN
          422708-1MG 04055977187243
          422708-5MG 04055977187250

          Documentation

          KN-93 - CAS 139298-40-1 - Calbiochem MSDS

          Titolo

          Scheda di sicurezza (MSDS) 

          KN-93 - CAS 139298-40-1 - Calbiochem Certificati d'Analisi

          TitoloNumero di lotto
          422708

          Riferimenti bibliografici

          Panoramica delle referenze
          Fan, G.H., et al. 1999. Mol. Pharmacol. 56, 39.
          Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
          Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
          Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
          Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
          Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.

          Brochure

          Titolo
          Caspases and other Apoptosis Related Tools Brochure
          Scheda tecnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-November-2009 RFH
          Synonyms2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine)
          DescriptionCell-permeable, reversible, and competitive inhibitor of rat brain Ca+2/calmodulin-dependent protein kinase II (Ki = 370 nM). KN-93 selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
          FormOff-white solid
          CAS number139298-40-1
          Chemical formulaC₂₆H₂₉CIN₂O₄S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage Protect from light
          +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Toxicity Irritant
          ReferencesFan, G.H., et al. 1999. Mol. Pharmacol. 56, 39.
          Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
          Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
          Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
          Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
          Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.

          Prodotti e applicazioni correlate

          Alternative Products

          Numero di catalogo Descrizione  
          422711 KN-93, Water-Soluble - Calbiochem Prezzi e disponibilità

          Categorie

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors