Millipore Sigma Vibrant Logo

402088 Indirubin-3ʹ-monoxime-5-sulphonic Acid - CAS 331467-05-1 - Calbiochem

A potent, reversible, and selective inhibitor of Cdk1 (IC₅₀ = 5 nM) and Cdk5 (IC₅₀ = 7 nM) and glycogen synthase kinase-3β (GSK-3β; IC₅₀ = 80 nM).

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Primary Target: CDK1
View Products on Sigmaaldrich.com
402088
Visualizza prezzi e disponibilità

Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
331467-05-1C₁₆H₁₁N₃O₅S

Prezzi e disponibilità

Numero di catalogo DisponibilitàConfezionamento Qtà/conf Prezzo Quantità
402088-1MG
Verifica della disponibilità in corso...
—
Disponibilità limitata Disponibilità limitata
A magazzino 
Fuori produzione
Disponibili quantità limitate
La disponibilità deve essere confermata
    Prodotti rimanenti: riceverà un nostro avviso
      Prodotti rimanenti: riceverà un nostro avviso
      Will advise
      Contatti il Servizio Clienti
      Contact Customer Service

      		 Fiala di plastica 1 mg
      Ricerca del prezzo in corso...
      Non è stato possibile trovare il prezzo
      La quantità minima deve essere un multiplo di
      Maximum Quantity is
      Al termine dell'ordine Maggiori informazioni
      Lei ha salvato ()
       
      —
      Richiedi il prezzo
      		 —
      Description
      OverviewA potent, reversible, and selective inhibitor of Cdk1 (IC50 = 5 nM) and Cdk5 (IC50 = 7 nM) and glycogen synthase kinase-3β (GSK-3β; IC50 = 80 nM). The inhibition is competitive with respect to ATP.
      Catalogue Number402088
      Brand Family Calbiochem®
      References
      ReferencesLeclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
      Product Information
      CAS number331467-05-1
      ATP CompetitiveY
      FormDark red solid
      Hill FormulaC₁₆H₁₁N₃O₅S
      Chemical formulaC₁₆H₁₁N₃O₅S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCDK1
      Primary Target IC<sub>50</sub>5 nM, 7 nM, 80 nM, against Cdk1, Cdk5, and glycogen synthase kinase-3β (GSK-3β), respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      402088-1MG 04055977211801

      Documentation

      Indirubin-3ʹ-monoxime-5-sulphonic Acid - CAS 331467-05-1 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Indirubin-3ʹ-monoxime-5-sulphonic Acid - CAS 331467-05-1 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      402088

      Riferimenti bibliografici

      Panoramica delle referenze
      Leclerc, S., et al. 2001. J. Biol. Chem. 276, 251.

      Brochure

      Titolo
      Alzheimer's Disease Brochure & Technical Guide
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      DescriptionA highly potent, reversible, and selective inhibitor of cyclin-dependent kinases 1 and 5 (IC50 = 5 nM for CDK1; IC50 = 7 nM for CDK5). Reported to act by competing with ATP for binding to the catalytic site of the kinase. Also acts as a potent inhibitor of glycogen synthase kinase-3β (GSK-3β; IC50 = 80 nM).
      FormDark red solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number331467-05-1
      Chemical formulaC₁₆H₁₁N₃O₅S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesLeclerc, S., et al. 2001. J. Biol. Chem. 276, 251.