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565784 InSolution™ γ-Secretase Inhibitor IX - Calbiochem

InSolution™ g-Secretase Inhibitor IX, CAS 208255-80-5, is a 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of g-secretase Inhibitor IX (DAPT; Cat. No. 565770) in DMSO.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT

Primary Target: Aβtotal
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565784
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₂₃H₂₆F₂N₂O₄

Prezzi e disponibilità

Numero di catalogo DisponibilitàConfezionamento Qtà/conf Prezzo Quantità
565784-10MG
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      		 Fiala di plastica 10 mg
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      565784-5MG
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          		 Bottiglia di vetro 5 mg
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          Description
          Catalogue Number565784
          Brand Family Calbiochem®
          SynonymsN-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT
          References
          ReferencesOddo, S., et al. 2004. Neuron 43, 321.
          Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
          Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.
          Product Information
          ATP CompetitiveN
          FormClear colorless liquid
          FormulationA 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565770) in DMSO.
          Hill FormulaC₂₃H₂₆F₂N₂O₄
          Chemical formulaC₂₃H₂₆F₂N₂O₄
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetAβtotal
          Primary Target IC<sub>50</sub>115 nM, 200 nM against Aβtotal, Aβ42, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Numero di catalogo GTIN
          565784-10MG 04055977267303
          565784-5MG 04055977191806

          Documentation

          InSolution™ γ-Secretase Inhibitor IX - Calbiochem MSDS

          Titolo

          Scheda di sicurezza (MSDS) 

          InSolution™ γ-Secretase Inhibitor IX - Calbiochem Certificati d'Analisi

          TitoloNumero di lotto
          565784

          Riferimenti bibliografici

          Panoramica delle referenze
          Oddo, S., et al. 2004. Neuron 43, 321.
          Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
          Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.

          Citazioni

          Titolo
        • Yunzhou Dong, et al. (2006) Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation. FASEB Journal in press,.
        • Yasuhiko Kawakami, et al. (2005) Retinoic acid signalling links leftright asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435, 165-171.
        • Aurelie Olivier, et al. (2005) The Notch ligand delta-1 is a hematopoietic development co- factor for plasmacytoid dendritic cells. Blood 107, 2694-2701.
          		•
          Scheda tecnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-January-2013 JSW
          SynonymsN-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT
          DescriptionA cell-permeable dipeptide that inhibits γ-secretase activity and suppresses Aβ production (Aβ total IC50 = 115 nM; Aβ42 IC50 = 200 nM). Reported to be functionally active in both HEK293 cells overexpressing human APP751 and neuronal cultures, however, it does not affect the secretion of amyloid-b precursor protein (APP). Effective in acutely lowering Ab in APPV717F-transgenic mice. Also effective in inhibiting the production of a ~6 kDa C-terminal cleavage product (CTFg) in HEK293 cells stably transfected with the Swedish mutant, βAPP695. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice.
          FormClear colorless liquid
          FormulationA 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565770) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₃H₂₆F₂N₂O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage Protect from light
          +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesOddo, S., et al. 2004. Neuron 43, 321.
          Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
          Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.
          Citation
        • Yunzhou Dong, et al. (2006) Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation. FASEB Journal in press,.
        • Yasuhiko Kawakami, et al. (2005) Retinoic acid signalling links leftright asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435, 165-171.
        • Aurelie Olivier, et al. (2005) The Notch ligand delta-1 is a hematopoietic development co- factor for plasmacytoid dendritic cells. Blood 107, 2694-2701.
          		•