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573130 InSolution™ STAT3 Inhibitor VI, S3I-201 - Calbiochem

The InSolution™ STAT3 Inhibitor VI, S3I-201, also referenced under CAS 501919-59-1, controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
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573130
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₆H₁₅NO₇S

Prezzi e disponibilità

Numero di catalogo DisponibilitàConfezionamento Qtà/conf Prezzo Quantità
573130-5MG
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      Description
      OverviewA cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in vitro (effective conc. ≤100 µM) and in a murine xenograft model in vivo (5 mg/kg, i.v.). The solid form of this compound (Cat. No. 573102) is also available.
      Catalogue Number573130
      Brand Family Calbiochem®
      References
      ReferencesLin, L., et al. 2009. Oncogene, 28, 961.
      Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7391.
      Product Information
      FormLiquid
      FormulationA 50 mM (5 mg/274 µl) solution of STAT3 Inhibitor VI, S3I-201 (Cat. No. 573102) in DMSO.
      Hill FormulaC₁₆H₁₅NO₇S
      Chemical formulaC₁₆H₁₅NO₇S
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      573130-5MG 04055977190205

      Documentation

      InSolution™ STAT3 Inhibitor VI, S3I-201 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      InSolution™ STAT3 Inhibitor VI, S3I-201 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      573130

      Riferimenti bibliografici

      Panoramica delle referenze
      Lin, L., et al. 2009. Oncogene, 28, 961.
      Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7391.

      Informazioni tecniche

      Titolo
      JAK/STAT Signaling Research Focus
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-February-2012 RFH
      DescriptionA cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in vitro (effective conc. ≤100 µM) and in a murine xenograft model in vivo (5 mg/kg, i.v.).
      FormLiquid
      FormulationA 50 mM (5 mg/274 µl) solution of STAT3 Inhibitor VI, S3I-201 (Cat. No. 573102) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₆H₁₅NO₇S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesLin, L., et al. 2009. Oncogene, 28, 961.
      Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7391.