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557364 InSolution™ Roscovitine - Calbiochem

InSolution™ Roscovitine - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Primary Target: p34cdk1/cyclin B
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557364
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₉H₂₆N₆O

Prezzi e disponibilità

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557364-5MG
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      Description
      Catalogue Number557364
      Brand Family Calbiochem®
      References
      ReferencesMeijer, L. 1996. Trends Cell Biol. 6, 393.
      Rudolph, B., et al. 1996. EMBO J. 15, 3053.
      Product Information
      ATP CompetitiveY
      DeclarationSold under license of U.S. Patent 6,316,456.
      FormLiquid
      FormulationA 50 mM (5 mg/282 µl) solution of Roscovitine (Cat. No. 557360) in DMSO.
      Hill FormulaC₁₉H₂₆N₆O
      Chemical formulaC₁₉H₂₆N₆O
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetp34cdk1/cyclin B
      Primary Target IC<sub>50</sub>650 nM, 700 nM, 700 nM, and 200 nM against p34cdk1/cyclin B, p33cdk2/cyclin A, p33cdk2/cyclin E, and p33cdk5/p35, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and freeze (-20°C). Once opened, the DMSO aliquots are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      557364-5MG 04055977268010

      Documentation

      InSolution™ Roscovitine - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      InSolution™ Roscovitine - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      557364

      Riferimenti bibliografici

      Panoramica delle referenze
      Meijer, L. 1996. Trends Cell Biol. 6, 393.
      Rudolph, B., et al. 1996. EMBO J. 15, 3053.

      Citazioni

      Titolo
    • Marc Payton, et al. (2006) Discovery and Evaluation of Dual CDK1 and CDK2 Inhibitors. Cancer Research 66, 4299-4308.
    • Meng Qiao, et al. (2006) Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. Journal of Biological Chemistry 281, 7118-7128.
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
    • Oscar M. Tirado, Silvia Mateo-Lozano and Vicente Notario. (2005) Roscovitine is an effective inducer of apoptosis of Ewing's sarcoma family of tumor cells in vitro and in vivo. Cancer Research 65, 9320-9327.
      		•
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-February-2008 JSW
      DescriptionA potent and selective inhibitor of cyclin-dependent kinases (Cdks). Exhibits greater inhibitory potency compared to olomoucine (Cat. No. 495620). Inhibits p34 Cdc2/cyclin B (IC50 = 650 nM), p33 Cdk2/cyclin A (IC50 = 700 nM), p33 Cdk2/cyclin E (IC50 = 700 nM), and p33 Cdk2/p35 (IC50 = 200 nM) by competing for the ATP binding domain of these kinases. Exhibits very low sensitivity towards related kinases, such as Erk1 and Erk2 (IC50 = 34 µM and 14 µM, respectively). Roscovitine does not significantly affect the activity of other protein kinases even at 100 µM and compared to olomoucine, roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle.
      FormLiquid
      FormulationA 50 mM (5 mg/282 µl) solution of Roscovitine (Cat. No. 557360) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₉H₂₆N₆O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and freeze (-20°C). Once opened, the DMSO aliquots are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesMeijer, L. 1996. Trends Cell Biol. 6, 393.
      Rudolph, B., et al. 1996. EMBO J. 15, 3053.
      Citation
    • Marc Payton, et al. (2006) Discovery and Evaluation of Dual CDK1 and CDK2 Inhibitors. Cancer Research 66, 4299-4308.
    • Meng Qiao, et al. (2006) Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. Journal of Biological Chemistry 281, 7118-7128.
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
    • Oscar M. Tirado, Silvia Mateo-Lozano and Vicente Notario. (2005) Roscovitine is an effective inducer of apoptosis of Ewing's sarcoma family of tumor cells in vitro and in vivo. Cancer Research 65, 9320-9327.
      		•