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422712 InSolution™ KN-93 - CAS 139298-40-1 - Calbiochem

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Primary Target: cam kinase 2
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422712
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Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
139298-40-1C₂₆H₂₉ClN₂O₄S

Prezzi e disponibilità

Numero di catalogo DisponibilitàConfezionamento Qtà/conf Prezzo Quantità
422712-1MG
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      Description
      Catalogue Number422712
      Brand Family Calbiochem®
      References
      ReferencesFan, G.H., et al. 1999. Mol. Pharmacol. 56, 39.
      Tombes, R.M., et al. 1995. Cell Growth Differentiation 6, 1063.
      Chen, C., et al. 1994. Science 266, 291.
      Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
      Niki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
      Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
      Product Information
      CAS number139298-40-1
      ATP CompetitiveN
      FormLiquid
      FormulationA 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422708) in DMSO.
      Hill FormulaC₂₆H₂₉ClN₂O₄S
      Chemical formulaC₂₆H₂₉ClN₂O₄S
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcam kinase 2
      Primary Target K<sub>i</sub>370 nM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      422712-1MG 04055977187281

      Documentation

      InSolution™ KN-93 - CAS 139298-40-1 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      InSolution™ KN-93 - CAS 139298-40-1 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      422712

      Riferimenti bibliografici

      Panoramica delle referenze
      Fan, G.H., et al. 1999. Mol. Pharmacol. 56, 39.
      Tombes, R.M., et al. 1995. Cell Growth Differentiation 6, 1063.
      Chen, C., et al. 1994. Science 266, 291.
      Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
      Niki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
      Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-January-2023 JSW
      DescriptionA cell-permeable, competitive inhibitor of Ca2+/calmodulin-dependent protein kinase II (Ki = 370 nM). Selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
      FormLiquid
      FormulationA 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422708) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number139298-40-1
      Chemical formulaC₂₆H₂₉ClN₂O₄S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesFan, G.H., et al. 1999. Mol. Pharmacol. 56, 39.
      Tombes, R.M., et al. 1995. Cell Growth Differentiation 6, 1063.
      Chen, C., et al. 1994. Science 266, 291.
      Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
      Niki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
      Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.