171261 Sigma-AldrichInSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem
InSolution™ AMPK Inhibitor, Compound C, CAS 866405-64-3, is a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO.
More>> InSolution™ AMPK Inhibitor, Compound C, CAS 866405-64-3, is a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO. Less<<MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Sinonimi: Dorsomorphin, BMP Inhibitor I, AMPK Inhibitor I
Prodotti consigliati
Panoramica
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Tabella delle specifiche principali
| CAS # | Empirical Formula |
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| 866405-64-3 | C₂₄H₂₅N₅O |
Prezzi e disponibilità
| Numero di catalogo | Disponibilità | Confezionamento | Qtà/conf | Prezzo | Quantità | |
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| 171261-1MG |
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Fiala di plastica | 1 mg |
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| Description | |
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| Overview | A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. |
| Catalogue Number | 171261 |
| Brand Family | Calbiochem® |
| Synonyms | Dorsomorphin, BMP Inhibitor I, AMPK Inhibitor I |
| Product Information | |
|---|---|
| CAS number | 866405-64-3 |
| ATP Competitive | Y |
| Form | Liquid |
| Formulation | Supplied as a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO. |
| Hill Formula | C₂₄H₂₅N₅O |
| Chemical formula | C₂₄H₂₅N₅O |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Numero di catalogo | GTIN |
| 171261-1MG | 04055977207170 |
Documentation
InSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem MSDS
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InSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem Certificati d'Analisi
| Titolo | Numero di lotto |
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| 171261 |
Riferimenti bibliografici
| Panoramica delle referenze |
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| Hao, J., et al. 2010. ACS Chem.Biol. 5, 245. Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970. Lee, M., et al. 2003. J. Biol. Chem. 278, 39653. Inoki, K., et al. 2003. Cell 115, 577. Fryer, L.G., 2002. FEBS Lett. 531, 189. Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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