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382175 Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem

The Histone Deacetylase Inhibitor VIII, also referenced under CAS 1045792-66-2, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: HDAC Inhibitor VIII, N-(4-(3-(((7-Hydroxyamino-7-oxoheptyl)amino)carbonyl)-5-isoxazolyl)phenyl)-1,1-dimethylethylester, carbamic acid

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382175
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Tabella delle specifiche principali

CAS #Empirical Formula
1045792-66-2C₂₂H₃₀N₄O₆

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382175-1MG
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      Description
      OverviewA cell-permeable, active site Zn2+-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC50 = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC50 <1.0 µM).
      Catalogue Number382175
      Brand Family Calbiochem®
      SynonymsHDAC Inhibitor VIII, N-(4-(3-(((7-Hydroxyamino-7-oxoheptyl)amino)carbonyl)-5-isoxazolyl)phenyl)-1,1-dimethylethylester, carbamic acid
      References
      ReferencesKozikowski, A.P., et al. 2008. J. Med. Chem. 51, 4370.
      Product Information
      CAS number1045792-66-2
      FormBeige to light brown solid
      Hill FormulaC₂₂H₃₀N₄O₆
      Chemical formulaC₂₂H₃₀N₄O₆
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      382175-1MG 04055977212808

      Documentation

      Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      382175

      Riferimenti bibliografici

      Panoramica delle referenze
      Kozikowski, A.P., et al. 2008. J. Med. Chem. 51, 4370.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-November-2010 JSW
      SynonymsHDAC Inhibitor VIII, N-(4-(3-(((7-Hydroxyamino-7-oxoheptyl)amino)carbonyl)-5-isoxazolyl)phenyl)-1,1-dimethylethylester, carbamic acid
      DescriptionA cell-permeable, active site Zn2+-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC50 = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC50 <1.0 µM).
      FormBeige to light brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1045792-66-2
      Chemical formulaC₂₂H₃₀N₄O₆
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKozikowski, A.P., et al. 2008. J. Med. Chem. 51, 4370.