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368055 Granzyme B Inhibitor II - CAS 1258003-96-1 - Calbiochem

The Granzyme B Inhibitor II, also referenced under CAS 1258003-96-1, controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Caspase-8 Inhibitor I, Ac-IETD-CHO

Primary Target: caspase-8
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Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
1258003-96-1C₂₁H₃₄N₄O₁₀

Prezzi e disponibilità

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368055-1MG
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      Description
      OverviewA potent, reversible inhibitor of granzyme B and caspase-8 (Ki = 1 nM). Also inhibits caspase-1 (<6 nM), caspase-6 (5.6 nM), and caspase-10 (27 nM).
      Catalogue Number368055
      Brand Family Calbiochem®
      SynonymsCaspase-8 Inhibitor I, Ac-IETD-CHO
      References
      ReferencesGao, C.F., et al. 2001. Exp. Cell. Res. 265, 145.
      Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.
      Product Information
      CAS number1258003-96-1
      ATP CompetitiveN
      FormWhite lyophilized solid
      Hill FormulaC₂₁H₃₄N₄O₁₀
      Chemical formulaC₂₁H₃₄N₄O₁₀
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcaspase-8
      Primary Target K<sub>i</sub>1 nM against caspase-8
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceAc-Ile-Glu-Thr-Asp-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      368055-1MG 04055977192131

      Documentation

      Granzyme B Inhibitor II - CAS 1258003-96-1 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Granzyme B Inhibitor II - CAS 1258003-96-1 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      368055

      Riferimenti bibliografici

      Panoramica delle referenze
      Gao, C.F., et al. 2001. Exp. Cell. Res. 265, 145.
      Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.

      Brochure

      Titolo
      Caspases and other Apoptosis Related Tools Brochure
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-March-2011 RFH
      SynonymsCaspase-8 Inhibitor I, Ac-IETD-CHO
      DescriptionPotent, reversible granzyme B and caspase-8 inhibitor.
      FormWhite lyophilized solid
      CAS number1258003-96-1
      Chemical formulaC₂₁H₃₄N₄O₁₀
      Peptide SequenceAc-Ile-Glu-Thr-Asp-CHO
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (1 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGao, C.F., et al. 2001. Exp. Cell. Res. 265, 145.
      Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.

      Prodotti e applicazioni correlate

      Alternative Products

      Numero di catalogo Descrizione  
      368050 Granzyme B Inhibitor I - Calbiochem Prezzi e disponibilità

      Categorie

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Granzyme Inhibitors