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361546 GSK-3β Peptide Inhibitor, Cell-permeable - Calbiochem

The GSK-3β Peptide Inhibitor, Cell-permeable controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: L803-mts, Myr-N-GKEAPPAPPQSpP-NH₂

Primary Target: Gsk-3β
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361546
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Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₆₆H₁₁₀N₁₅O₂₀P

Prezzi e disponibilità

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361546-1MG
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      Description
      OverviewA cell-permeable myristoylated form of GSK-3β Peptide Inhibitor (Cat. No. 361545) with a glycine spacer. Acts as a selective, substrate-specific, competitive inhibitor of GSK-3β (IC50 = 40 µM). Does not affect the activities of Cdc2, PKB, and PKC. Shown to mimic insulin action, and activate glycogen synthase activity (~2.5-fold) in HEK293 cells and improve glucose tolerance in diabetic mice. Displays in vivo stability.
      Catalogue Number361546
      Brand Family Calbiochem®
      SynonymsL803-mts, Myr-N-GKEAPPAPPQSpP-NH₂
      References
      ReferencesPlotkin, B., et al. 2003. J. Pharmacol. Exp. Ther. 305, 974.
      Product Information
      ATP CompetitiveN
      DeclarationThis product is covered by one or more US patents and/or patent applications and foreign counter-parts owned by Tel Aviv University Future Technology LP, a limited partnership formed under the laws of Israel. Purchase of this product conveys a non-exclusive license to use the product for research purposes only. Purchase of this product does not convey the right to (i) incorporate or use the product in the manufacture of any commercial product, (ii) sell or otherwise transfer the product to any third party, or (iii) use the product to provide any commercial service. THE PRODUCT IS NOT FOR USE IN HUMANS. For information on purchasing a license to this product for purposes other than research, contact VP Business Development, Ramot at Tel Aviv University Ltd., Tel Aviv University, Licensor-Aviv, Tel Aviv 61392, Israel, Phone: +972 3 640 6608; Fax: +972 3 640 6675.
      FormLyophilized white solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₆₆H₁₁₀N₁₅O₂₀P
      Chemical formulaC₆₆H₁₁₀N₁₅O₂₀P
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGsk-3β
      Primary Target IC<sub>50</sub>40 µM against Gsk-3β
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceMyr-N-Gly-Lys-Glu-Ala-Pro-Pro-Ala-Pro-Pro-Gln-Ser(PO₃H)-Pro-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      361546-1MG 04055977214024

      Documentation

      GSK-3β Peptide Inhibitor, Cell-permeable - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      GSK-3β Peptide Inhibitor, Cell-permeable - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      361546

      Riferimenti bibliografici

      Panoramica delle referenze
      Plotkin, B., et al. 2003. J. Pharmacol. Exp. Ther. 305, 974.

      Brochure

      Titolo
      Alzheimer's Disease Brochure & Technical Guide
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-July-2008 RFH
      SynonymsL803-mts, Myr-N-GKEAPPAPPQSpP-NH₂
      DescriptionA cell-permeable myristoylated form of GSK-3β Peptide Inhibitor (Cat. No. 361545) with a glycine spacer. Acts as a selective, substrate-specific, competitive inhibitor of GSK-3β (IC50 = 40 µM). Does not affect the activities of Cdc-2, PKB, or PKC. Shown to mimic insulin action, and activate glycogen synthase activity (~ 2.5-fold) in HEK293 cells. Also reported to improve glucose tolerance in diabetic mice. Exhibits greater in vivo stability.
      FormLyophilized white solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₆₆H₁₁₀N₁₅O₂₀P
      Peptide SequenceMyr-N-Gly-Lys-Glu-Ala-Pro-Pro-Ala-Pro-Pro-Gln-Ser(PO₃H)-Pro-NH₂
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml) or CH₃CN:H₂O (1:1) (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesPlotkin, B., et al. 2003. J. Pharmacol. Exp. Ther. 305, 974.