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371830 GPR40 Antagonist, GW1100 - CAS 306974-70-9 - Calbiochem

The GPR40 Antagonist, GW1100, also referenced under CAS 306974-70-9, controls the biological activity of GPR40. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone, SB376752

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371830
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Tabella delle specifiche principali

CAS #Empirical Formula
306974-70-9C₂₇H₂₅FN₄O₄S

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371830-10MG
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      Description
      OverviewA cell-permeable pyrimidinylmethyl-pyrimidinone compound that acts as potent, reversible and non-competitive GPR40 antagonist. Selectively blocks GPR40-mediated intracellular Ca2+ release stimulated by GPR40 Agonist GW9508 (Cat. No. 371706) and linoleic acid (pIC50 of 5.99 in GPR40 expressing HEK293 cells) with no effect on GPR120-mediated activation. Shown to significantly reverse glucose-induced insulin secretion potentiated by GW9508 and only partially reduce linoleic acid effect in MIN6 cells.
      Catalogue Number371830
      Brand Family Calbiochem®
      Synonyms1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone, SB376752
      References
      ReferencesStoddart, L.A., et al. 2007. Mol. Pharmacol. 71, 994.
      Briscoe, C.P., et al. 2006. Br. J. Pharmacol. 148, 619.
      Product Information
      CAS number306974-70-9
      FormWhite powder
      Hill FormulaC₂₇H₂₅FN₄O₄S
      Chemical formulaC₂₇H₂₅FN₄O₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      371830-10MG 04055977213478

      Documentation

      GPR40 Antagonist, GW1100 - CAS 306974-70-9 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      GPR40 Antagonist, GW1100 - CAS 306974-70-9 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      371830

      Riferimenti bibliografici

      Panoramica delle referenze
      Stoddart, L.A., et al. 2007. Mol. Pharmacol. 71, 994.
      Briscoe, C.P., et al. 2006. Br. J. Pharmacol. 148, 619.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-August-2012 JSW
      Synonyms1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone, SB376752
      DescriptionA cell-permeable pyrimidinylmethyl-pyrimidinone compound that acts as potent, reversible and non-competitive GPR40 antagonist. Selectively blocks GPR40-mediated intracellular Ca2+ release stimulated by GPR40 Agonist GW9508 (Cat. No. 371706) and linoleic acid (pIC50 of 5.99 in GPR40 expressing HEK293 cells) with no effect on GPR120-mediated activation. Shown to significantly reverse glucose-induced insulin secretion potentiated by GW9508 and only partially reduce linoleic acid effect in MIN6 cells.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number306974-70-9
      Chemical formulaC₂₇H₂₅FN₄O₄S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesStoddart, L.A., et al. 2007. Mol. Pharmacol. 71, 994.
      Briscoe, C.P., et al. 2006. Br. J. Pharmacol. 148, 619.