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344092 Formin FH2 Domain Inhibitor, SMIFH2 - CAS 340316-62-3 - Calbiochem

Formin FH2 Domain Inhibitor, SMIFH2, CAS 340316-62-3, is a cell-permeable inhibitor of formin-mediated actin nucleation (IC50 ~15 µM) and formin-mediated elongation of actin filaments.

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Sinonimi: Small Molecule Inhibitor of Formin Homology 2 domain, 1-(3-Bromophenyl)-5-(2-furylmethylene)-2-thioxo-hexahydropyrimidine-4,6-dione, Actin Assembly Inhibitor XV

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344092
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CAS #Empirical Formula
340316-62-3C₁₅H₉BrN₂O₃S

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      Description
      OverviewA cell-permeable thiooxodihydropyrimidinedione compound that inhibits both formin-mediated, profilin-independent actin nucleation (IC50 ~15 µM using mDia1 or mDia2) and formin-mediated elongation of actin filaments in the presence of profilin (IC50 ~4 µM using Cdc12 or mDia2), but not the Arp2/3-mediated or formin-independent actin assembly. SMIFH2 targets the FH2 (formin homology 2) domain of formins from a large variety of species, including murine mDia1/2, C. elegans CYK-1, S. pombe Cdc12, S. pombe Fus1, and S. cerevisiae Bni1, and decreases formin affinity for the actin filament barbed end. SMIFH2, at 25 µM, is shown to selectively disrupt formin-dependent actin cables and contractile rings, but not Arp2/3-dependent, CK-666- (Cat. No. 182515) sensitive actin patches, in fission yeast. SMIFH2 is also demonstrated to affect F-actin cytoskeleton structures and cell migration (by a 2-fold decrease at 10 µM) in NIH 3T3 fibroblast cultures.
      Catalogue Number344092
      Brand Family Calbiochem®
      SynonymsSmall Molecule Inhibitor of Formin Homology 2 domain, 1-(3-Bromophenyl)-5-(2-furylmethylene)-2-thioxo-hexahydropyrimidine-4,6-dione, Actin Assembly Inhibitor XV
      References
      ReferencesRizvi, S.A., et al. 2009. Chem. Biol. 16, 1158.
      Product Information
      CAS number340316-62-3
      FormDark to deep green solid
      Hill FormulaC₁₅H₉BrN₂O₃S
      Chemical formulaC₁₅H₉BrN₂O₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationFormin FH2 Domain Inhibitor, SMIFH2, CAS 340316-62-3, is a cell-permeable inhibitor of formin-mediated actin nucleation (IC50 ~15 µM) and formin-mediated elongation of actin filaments.
      Biological Information
      Purity≥98% by HPLC (sum of two geometrical isomers)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsUse only fresh DMSO. Following reconstiution, aliquot an freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      344092-10MG 04055977194579

      Documentation

      Formin FH2 Domain Inhibitor, SMIFH2 - CAS 340316-62-3 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Formin FH2 Domain Inhibitor, SMIFH2 - CAS 340316-62-3 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      344092

      Riferimenti bibliografici

      Panoramica delle referenze
      Rizvi, S.A., et al. 2009. Chem. Biol. 16, 1158.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2016 JSW
      SynonymsSmall Molecule Inhibitor of Formin Homology 2 domain, 1-(3-Bromophenyl)-5-(2-furylmethylene)-2-thioxo-hexahydropyrimidine-4,6-dione, Actin Assembly Inhibitor XV
      DescriptionA cell-permeable thiooxodihydropyrimidinedione compound that inhibits both formin-mediated, profilin-independent actin nucleation (IC50 ~15 µM using mDia1 or mDia2) and formin-mediated elongation of actin filaments in the presence of profilin (IC50 ~4 µM using Cdc12 or mDia2), but not the Arp2/3-mediated or formin-independent actin assembly. SMIFH2 targets the FH2 (formin homology 2) domain of formins from a large variety of species, including murine mDia1/2, C. elegans CYK-1, S. pombe Cdc12, S. pombe Fus1, and S. cerevisiae Bni1, and decreases formin affinity for the actin filament barbed end. SMIFH2, at 25 µM, is shown to selectively disrupt formin-dependent actin cables and contractile rings, but not Arp2/3-dependent, CK-666- (Cat. No. 182515) sensitive actin patches, in fission yeast. SMIFH2 is also demonstrated to affect F-actin cytoskeleton structures and cell migration (by a 2-fold decrease at 10 µM) in NIH 3T3 fibroblast cultures.
      FormDark to deep green solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number340316-62-3
      Chemical formulaC₁₅H₉BrN₂O₃S
      Structure formulaStructure formula
      Purity≥98% by HPLC (sum of two geometrical isomers)
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsUse only fresh DMSO. Following reconstiution, aliquot an freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesRizvi, S.A., et al. 2009. Chem. Biol. 16, 1158.