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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

324683 Sigma-AldrichEllagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem

A cell-permeable, reversible, potent antioxidant that has anti-mutagenic and anti-carcinogenic properties.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

MSDS
Cert. d'Analisi
Riferimenti bibliografici
Data Sheet

Sinonimi: 4,4ʹ,5,5ʹ,6,6ʹ-Hexahydroxydiphenic Acid 2,6,2ʹ,6ʹ-Dilactone, TBBD, PRMT Inhibitor II

Primary Target: CDK2

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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #	Empirical Formula
476-66-4	C₁₄H₆O₈ · 2H₂O

Prezzi e disponibilità

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Description
Overview	A cell-permeable, reversible, potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Acts as a selective and ATP-competitive inhibitor of CK2 (IC₅₀ = 40 nM). Moderately inhibits DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC₅₀ = 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, respectively). Only minimally inhibits DYRK1a, CSK, RET, Flt3, and NPM-ALK (IC₅₀ >40 µM). Shown to act as an uncompetitive inhibitor of arginine methyltransferase CARM1 and block histone H3R17 methylation.
Catalogue Number	324683
Brand Family	Calbiochem®
Synonyms	4,4ʹ,5,5ʹ,6,6ʹ-Hexahydroxydiphenic Acid 2,6,2ʹ,6ʹ-Dilactone, TBBD, PRMT Inhibitor II

References
References	Selvi, B.R., et al. 2009, J. Biol. Chem. In press. Cozza, G., et al. 2006. J. Med. Chem. 49, 2363. Wang, B.H., et al. 1998. Planta Med. 64, 195. Constantinou, A., et al. 1995. Nutr. Cancer 23, 121. Hickey, M.J., et al. 1995. Biochem. Soc. Trans. 23, 607s.

Product Information
CAS number	476-66-4
ATP Competitive	Y
Form	Slightly Beige Powder
Hill Formula	C₁₄H₆O₈ · 2H₂O
Chemical formula	C₁₄H₆O₈ · 2H₂O
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	CDK2
Primary Target IC<sub>50</sub>	40 nM against CK2; 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, against DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR, respectively
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	DJ2620000

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+15°C to +30°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 week at -20°C. Alkaline solutions are unstable and should be prepared just prior to use.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Numero di catalogo	GTIN
324683-500MG	04055977196856

Documentation

Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem MSDS

Titolo
Scheda di sicurezza (MSDS)

Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem Certificati d'Analisi

Titolo	Numero di lotto
324683	Digiti il numero di lotto

Riferimenti bibliografici

Panoramica delle referenze
Selvi, B.R., et al. 2009, J. Biol. Chem. In press. Cozza, G., et al. 2006. J. Med. Chem. 49, 2363. Wang, B.H., et al. 1998. Planta Med. 64, 195. Constantinou, A., et al. 1995. Nutr. Cancer 23, 121. Hickey, M.J., et al. 1995. Biochem. Soc. Trans. 23, 607s.

Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	06-February-2019 JSW
Synonyms	4,4ʹ,5,5ʹ,6,6ʹ-Hexahydroxydiphenic Acid 2,6,2ʹ,6ʹ-Dilactone, TBBD, PRMT Inhibitor II
Description	A cell-permeable, reversible, and potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Acts as a selective and ATP-competitive inhibitor of CK2 (IC₅₀ = 40 nM). Moderately inhibits DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC₅₀ = 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, respectively). Only minimally inhibits DYRK1a, CSK, RET, Flt3, and NPM-ALK (IC₅₀ >40 µM). Shown to act as an uncompetitive inhibitor of arginine methyltransferase CARM1 and block histone H3R17 methylation.
Form	Slightly Beige Powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	476-66-4
RTECS	DJ2620000
Chemical formula	C₁₄H₆O₈ · 2H₂O
Structure formula
Purity	≥98% by HPLC
Solubility	1 M NaOH (10 mg/ml) or Ethanol (10 mg/ml). For complete solubilization in ethanol, slight heating may be required.
Storage	Protect from light +15°C to +30°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 week at -20°C. Alkaline solutions are unstable and should be prepared just prior to use.
Toxicity	Irritant
Merck USA index	14, 3547
References	Selvi, B.R., et al. 2009, J. Biol. Chem. In press. Cozza, G., et al. 2006. J. Med. Chem. 49, 2363. Wang, B.H., et al. 1998. Planta Med. 64, 195. Constantinou, A., et al. 1995. Nutr. Cancer 23, 121. Hickey, M.J., et al. 1995. Biochem. Soc. Trans. 23, 607s.

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