Millipore Sigma Vibrant Logo

324630 EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem

The racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor and adenosine deaminase.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: erythro-9-(2-Hydroxy-3-nonyl)adenine, HCl

Primary Target: PDE 2
View Products on Sigmaaldrich.com
324630
Visualizza prezzi e disponibilità

Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
51350-19-7C₁₄H₂₃N₅O · HCl

Prezzi e disponibilità

Numero di catalogo DisponibilitàConfezionamento Qtà/conf Prezzo Quantità
324630-10MG
Verifica della disponibilità in corso...
—
Disponibilità limitata Disponibilità limitata
A magazzino 
Fuori produzione
Disponibili quantità limitate
La disponibilità deve essere confermata
    Prodotti rimanenti: riceverà un nostro avviso
      Prodotti rimanenti: riceverà un nostro avviso
      Will advise
      Contatti il Servizio Clienti
      Contact Customer Service

      		 Fiala di plastica 10 mg
      Ricerca del prezzo in corso...
      Non è stato possibile trovare il prezzo
      La quantità minima deve essere un multiplo di
      Maximum Quantity is
      Al termine dell'ordine Maggiori informazioni
      Lei ha salvato ()
       
      —
      Richiedi il prezzo
      		 —
      Description
      OverviewThe racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor (IC50 = 0.8 and 2 µM against human and procine PDE II, respectively) and adenosine deaminase (Ki = 4 nM), while exhibiting little or much reduced potency toward PDE I/II/IV isozymes (IC50 >100 µM) of both human and porcine species. EHNA at 10 µM concentration is also reported to effectively and reversibly block the differentiation and maintain the pluripotency of hES (human embryonic stem) cell line SA121 in feeder-free cultures without exogenously added FGF for up to 30 passages in a manner independent of its known ADA and PDE inhibitory activities.
      Catalogue Number324630
      Brand Family Calbiochem®
      Synonymserythro-9-(2-Hydroxy-3-nonyl)adenine, HCl
      References
      ReferencesBurton, P., et al. 2010. Biochem. J. in press.
      Lorbar, M., et al. 1999. J. Mol. Cell. Cardiol. 31, 401.
      Verde, I., et al. 1999. Br. J. Pharmacol. 127, 65.
      Reynolds, A.J., et al. 1996. Brain Res. 798, 67.
      Mery, P.F., et al. 1995. Mol. Pharmacol. 48, 121.
      Podzuweit, T., et al. 1995. Cell. Signal. 7, 733.
      Bessodes, M., et al. 1982. Biochem. Pharmacol. 31, 879.
      Bouchard, P., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 1033.
      Product Information
      CAS number51350-19-7
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₄H₂₃N₅O · HCl
      Chemical formulaC₁₄H₂₃N₅O · HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPDE 2
      Primary Target IC<sub>50</sub>0.8 and 2 µM against human and procine PDE II, respectively
      Primary Target K<sub>i</sub>4 nM against adenosine deaminase
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      324630-10MG 04055977196733

      Documentation

      EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      324630

      Riferimenti bibliografici

      Panoramica delle referenze
      Burton, P., et al. 2010. Biochem. J. in press.
      Lorbar, M., et al. 1999. J. Mol. Cell. Cardiol. 31, 401.
      Verde, I., et al. 1999. Br. J. Pharmacol. 127, 65.
      Reynolds, A.J., et al. 1996. Brain Res. 798, 67.
      Mery, P.F., et al. 1995. Mol. Pharmacol. 48, 121.
      Podzuweit, T., et al. 1995. Cell. Signal. 7, 733.
      Bessodes, M., et al. 1982. Biochem. Pharmacol. 31, 879.
      Bouchard, P., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 1033.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-February-2012 RFH
      Synonymserythro-9-(2-Hydroxy-3-nonyl)adenine, HCl
      DescriptionThe racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor (IC50 = 0.8 and 2 µM against human and procine PDE II, respectively) and adenosine deaminase (Ki = 4 nM), while exhibiting little or much reduced potency toward PDE I/II/IV isozymes (IC50 >100 µM) of both human and porcine species. EHNA at 10 µM concentration is also reported to effectively and reversibly block the differentiation and maintain the pluripotency of hES (human embryonic stem) cell line SA121 in feeder-free cultures without exogenously added FGF for up to 30 passages in a manner independent of its known ADA and PDE inhibitory activities.
      FormWhite solid
      CAS number51350-19-7
      Chemical formulaC₁₄H₂₃N₅O · HCl
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityH₂O (25 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesBurton, P., et al. 2010. Biochem. J. in press.
      Lorbar, M., et al. 1999. J. Mol. Cell. Cardiol. 31, 401.
      Verde, I., et al. 1999. Br. J. Pharmacol. 127, 65.
      Reynolds, A.J., et al. 1996. Brain Res. 798, 67.
      Mery, P.F., et al. 1995. Mol. Pharmacol. 48, 121.
      Podzuweit, T., et al. 1995. Cell. Signal. 7, 733.
      Bessodes, M., et al. 1982. Biochem. Pharmacol. 31, 879.
      Bouchard, P., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 1033.