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324890 E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem

E-64 Protease Inhibitor, CAS 66701-25-5, is an irreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: (2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide

Primary Target: cysteine proteases
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      Panoramica

      Replacement Information

      Tabella delle specifiche principali

      CAS #Empirical Formula
      66701-25-5C₁₅H₂₇N₅O₅
      Description
      OverviewIrreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.
      Catalogue Number324890
      Brand Family Calbiochem®
      Synonyms(2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide
      References
      ReferencesMatsumoto, K., et al. 1999. Biopolymers 51, 99.
      Sarin, A., et al. 1994. J. Immunol. 153, 862.
      Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
      Barrett, A.J. 1982. Biochem. J. 201, 189.
      Product Information
      CAS number66701-25-5
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₅H₂₇N₅O₅
      Chemical formulaC₁₅H₂₇N₅O₅
      HS Code2925 29 90
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      ApplicationE-64 Protease Inhibitor, CAS 66701-25-5, is an irreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins.
      Biological Information
      Primary Targetcysteine proteases
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSRR0390000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      324890 0

      Documentation

      E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      324890

      Riferimenti bibliografici

      Panoramica delle referenze
      Matsumoto, K., et al. 1999. Biopolymers 51, 99.
      Sarin, A., et al. 1994. J. Immunol. 153, 862.
      Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
      Barrett, A.J. 1982. Biochem. J. 201, 189.

      Citazioni

      Titolo
    • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
      		•
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-July-2013 JSW
      Synonyms(2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide
      DescriptionIrreversible inhibitor of cysteine proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.
      FormWhite solid
      CAS number66701-25-5
      RTECSRR0390000
      Chemical formulaC₁₅H₂₇N₅O₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (25 mg/ml) or H₂O (20 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesMatsumoto, K., et al. 1999. Biopolymers 51, 99.
      Sarin, A., et al. 1994. J. Immunol. 153, 862.
      Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
      Barrett, A.J. 1982. Biochem. J. 201, 189.
      Citation
    • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
      		•