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266788 Diacylglycerol Kinase Inhibitor II - CAS 120166-69-0 - Calbiochem

The Diacylglycerol Kinase Inhibitor II, also referenced under CAS 120166-69-0, controls the biological activity of Diacylglycerol KInase. This small molecule/inhibitor is primarily used for Phosphoryl

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Sinonimi: R59949, 3-{2-[4-[bis-(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl}-2,3-dihydro-2-thioxo-4(1H)quinazolinone, DGK Inhibitor II

Primary Target: Diacylglycerol Kinase
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266788
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CAS #Empirical Formula
120166-69-0C₂₈H₂₅F₂N₃OS

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266788-5MG
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      Description
      OverviewInhibits diacylglycerol kinase in isolated platelet membranes (IC50 = 300 nM) and in intact platelets (IC50 = 120 nM) by binding to the catalytic domain. A more potent analog of diacylglycerol kinase inhibitor I (Cat. No. 266785).
      Catalogue Number266788
      Brand Family Calbiochem®
      SynonymsR59949, 3-{2-[4-[bis-(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl}-2,3-dihydro-2-thioxo-4(1H)quinazolinone, DGK Inhibitor II
      References
      ReferencesJiang, Y., et al. 2000. Biochem. Pharmacol. 59, 763.
      Jones, D.R., et al. 1999. J. Biol. Chem. 274, 16846.
      Rodriguez-Linares, B., et al. 1991. Biochem. Pharmacol. 41, 835.
      de Chaffoy de Courcelles, D., et al. 1989. J. Biol. Chem. 264, 3274.
      Product Information
      CAS number120166-69-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₈H₂₅F₂N₃OS
      Chemical formulaC₂₈H₂₅F₂N₃OS
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetDiacylglycerol Kinase
      Primary Target IC<sub>50</sub>300 nM and 120 nM against diacylglycerol kinase in isolated platelet membranes and in intact platelets, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, flush with an inert gas and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Global Trade Item Number
      Numero di catalogo GTIN
      266788-5MG 04055977197778