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567727 D-erythro-Sphingosine-1-phosphate - CAS 26993-30-6 - Calbiochem

A putative second messenger that mobilizes calcium from intracellular stores via an IP3-independent pathway.

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567727
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Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
26993-30-6C₁₈H₃₈NO₅P

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567727-1MG
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      Description
      OverviewA putative second messenger that mobilizes calcium from intracellular stores via an IP3-independent pathway. Activates phospholipase D (PLD) and inhibits chemotactic motility and invasiveness of tumor cells. Also stimulates growth of quiescent Swiss/3T3 fibroblasts. Inhibits activation of caspases that cleave PARP and lamins during Fas- and ceramide-mediated apoptosis.
      Catalogue Number567727
      Brand Family Calbiochem®
      References
      ReferencesCuvillier, O., et al. 1998. J. Biol. Chem. 273, 2910.
      Mattie, M., et al. 1994. J. Biol. Chem. 269, 3181.
      Olivera, A. and Spiegel, S. 1993. Nature 365, 557.
      Desai, N.N., et al. 1992. J. Biol. Chem. 267, 23122.
      Sadahira, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 9686.
      Product Information
      CAS number26993-30-6
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₈H₃₈NO₅P
      Chemical formulaC₁₈H₃₈NO₅P
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMobilizes calcium from intracellular stores
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and evaporate under a stream of nitrogen. Store at -20°C. Prior to use, dissolve in 4 mg/ml BSA solution with vortexing. Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      567727-1MG 07790788051679

      Documentation

      D-erythro-Sphingosine-1-phosphate - CAS 26993-30-6 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      D-erythro-Sphingosine-1-phosphate - CAS 26993-30-6 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      567727

      Riferimenti bibliografici

      Panoramica delle referenze
      Cuvillier, O., et al. 1998. J. Biol. Chem. 273, 2910.
      Mattie, M., et al. 1994. J. Biol. Chem. 269, 3181.
      Olivera, A. and Spiegel, S. 1993. Nature 365, 557.
      Desai, N.N., et al. 1992. J. Biol. Chem. 267, 23122.
      Sadahira, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 9686.

      Brochure

      Titolo
      Bioactive Lipids Technical Bulletin
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-September-2008 RFH
      DescriptionA putative second messenger that mobilizes calcium from intracellular stores via an IP3 independent pathway. Activates phospholipase D and inhibits chemotactic motility and invasiveness of tumor cells. Also stimulates growth of quiescent Swiss 3T3 fibroblasts.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number26993-30-6
      Chemical formulaC₁₈H₃₈NO₅P
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityMethanol (0.5 mg/ml). Slight warming and vortexing may be required.
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and evaporate under a stream of nitrogen. Store at -20°C. Prior to use, dissolve in 4 mg/ml BSA solution with vortexing. Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Irritant
      ReferencesCuvillier, O., et al. 1998. J. Biol. Chem. 273, 2910.
      Mattie, M., et al. 1994. J. Biol. Chem. 269, 3181.
      Olivera, A. and Spiegel, S. 1993. Nature 365, 557.
      Desai, N.N., et al. 1992. J. Biol. Chem. 267, 23122.
      Sadahira, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 9686.