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239763 Cycloheximide - CAS 66-81-9 - Calbiochem

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Cycloheximide - CAS 66-81-9 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Primary Target: hFKBP12
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239763
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Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
66-81-9C₁₅H₂₃NO₄

Prezzi e disponibilità

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239763-1GM
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      239763-5GM
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          Description
          OverviewAn antifungal antibiotic that inhibits protein synthesis in eukaryotes but not prokaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and other cell types. A 100 mg/ml solution of Cycloheximide (Cat. No. 239765) in DMSO (sterile-filtered) is also available.
          Catalogue Number239763
          Brand Family Calbiochem®
          References
          ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
          Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
          Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
          Waring, P. 1990. J. Biol. Chem. 265, 14476.
          Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
          Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.
          Product Information
          CAS number66-81-9
          FormOff-white solid
          Hill FormulaC₁₅H₂₃NO₄
          Chemical formulaC₁₅H₂₃NO₄
          Structure formula ImageStructure formula Image
          Quality LevelMQ200
          Applications
          Biological Information
          Primary TargethFKBP12
          Primary Target K<sub>i</sub>3.4 µM
          Purity≥90% by assay
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSMA4375000
          Safety Information
          R PhraseR: 28-40-51/53-61

          Very toxic if swallowed.
          Limited evidence of a carcinogenic effect.
          Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
          May cause harm to the unborn child.
          S PhraseS: 45-53-61

          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Avoid exposure - obtain special instructions before use.
          Avoid release to the environment. Refer to special instructions/safety data sheet.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Numero di catalogo GTIN
          239763-1GM 07790788048907
          239763-5GM 07790788048914

          Documentation

          Cycloheximide - CAS 66-81-9 - Calbiochem MSDS

          Titolo

          Scheda di sicurezza (MSDS) 

          Cycloheximide - CAS 66-81-9 - Calbiochem Certificati d'Analisi

          TitoloNumero di lotto
          239763

          Riferimenti bibliografici

          Panoramica delle referenze
          Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
          Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
          Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
          Waring, P. 1990. J. Biol. Chem. 265, 14476.
          Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
          Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.

          Brochure

          Titolo
          Bulk Product Guide

          Citazioni

          Titolo
        • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
          		•
          Scheda tecnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-March-2019 JSW
          DescriptionAn antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Induces DNA fragmentation in macrophages, however it inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
          FormOff-white solid
          CAS number66-81-9
          RTECSMA4375000
          Chemical formulaC₁₅H₂₃NO₄
          Structure formulaStructure formula
          Purity≥90% by assay
          SolubilityChloroform, Ethanol, Methanol, or H₂O (10 mg/ml)
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 2728
          ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
          Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
          Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
          Waring, P. 1990. J. Biol. Chem. 265, 14476.
          Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
          Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.
          Citation
        • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
          		•