220486 Sigma-AldrichChk2 Inhibitor II - CAS 516480-79-8 - Calbiochem
Chk2 Inhibitor II, BML-277, CAS 516480-79-8 is a cell-permeable, potent, reversible, ATP-competitive inhibitor of Chk2 (IC₅₀ = 15 nM).
More>> Chk2 Inhibitor II, BML-277, CAS 516480-79-8 is a cell-permeable, potent, reversible, ATP-competitive inhibitor of Chk2 (IC₅₀ = 15 nM). Less<<Sinonimi: 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
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Tabella delle specifiche principali
CAS # | Empirical Formula |
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516480-79-8 | C₂₀H₁₄ClN₃O₂ |
Prezzi e disponibilità
Numero di catalogo | Disponibilità | Confezionamento | Qtà/conf | Prezzo | Quantità | |
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220486-1MG |
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Fiala di plastica | 1 mg |
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Description | |
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Overview | A cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC50 of 15 nM and a Ki of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 µM and 7.6 µM, respectively. Also available as a 25 mM solution in DMSO (Cat. No. 220491). |
Catalogue Number | 220486 |
Brand Family | Calbiochem® |
Synonyms | 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide |
References | |
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References | Arienti, K. L., et al. 2005. J. Med. Chem. 48, 1873. |
Product Information | |
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CAS number | 516480-79-8 |
ATP Competitive | Y |
Form | Pale yellow solid |
Hill Formula | C₂₀H₁₄ClN₃O₂ |
Chemical formula | C₂₀H₁₄ClN₃O₂ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
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Physicochemical Information | |
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Cell permeable | Y |
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Packaged under inert gas | Packaged under inert gas |
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Specifications |
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Global Trade Item Number | |
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Numero di catalogo | GTIN |
220486-1MG | 04055977201147 |
Documentation
Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem MSDS
Titolo |
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Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem Certificati d'Analisi
Titolo | Numero di lotto |
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220486 |
Riferimenti bibliografici
Panoramica delle referenze |
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Arienti, K. L., et al. 2005. J. Med. Chem. 48, 1873. |