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217694 Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem

The Cdc25 Inhibitor IV, NSC 95397, also referenced under CAS 93718-83-3, controls the biological activity of Cdc25. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: (2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX

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217694
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Tabella delle specifiche principali

CAS #Empirical Formula
93718-83-3C₁₄H₁₄O₄S₂

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217694-10MG
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      Description
      OverviewA cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50 = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments.
      Catalogue Number217694
      Brand Family Calbiochem®
      Synonyms(2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX
      References
      ReferencesDulyaninova, N.G., et al. 2011. Biochemistry 50, 7218.
      Lazo, J.S., et al. 2002. Mol. Pharmacol. 61, 720.
      Product Information
      CAS number93718-83-3
      FormOrange solid
      Hill FormulaC₁₄H₁₄O₄S₂
      Chemical formulaC₁₄H₁₄O₄S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      217694-10MG 04055977202304

      Documentation

      Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      217694

      Riferimenti bibliografici

      Panoramica delle referenze
      Dulyaninova, N.G., et al. 2011. Biochemistry 50, 7218.
      Lazo, J.S., et al. 2002. Mol. Pharmacol. 61, 720.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2012 JSW
      Synonyms(2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX
      DescriptionA cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50 = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments.
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number93718-83-3
      Chemical formulaC₁₄H₁₄O₄S₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml; clear red solution)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDulyaninova, N.G., et al. 2011. Biochemistry 50, 7218.
      Lazo, J.S., et al. 2002. Mol. Pharmacol. 61, 720.