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219343 Cathepsin S, Human, Recombinant, E. coli

Cathepsin S, Human, Recombinant, E. coli, is prepared without a tag or fusion protein. A major lysosomal cysteine proteinase with high specific activity.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
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219343
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Replacement Information

Prezzi e disponibilità

Numero di catalogo DisponibilitàConfezionamento Qtà/conf Prezzo Quantità
219343-25UG
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      Description
      OverviewRecombinant, human cathepsin S expressed in E. coli without a tag or fusion protein. A major lysosomal cysteine proteinase preferentially expressed in macrophages and microglia. Exhibits high specific activity.
      Note: 1 mU = 1 milliunit.
      Catalogue Number219343
      Brand Family Calbiochem®
      References
      ReferencesLiuzzo, J.P., et al. 1999. Mol. Med. 5, 334.
      Riese, R.J., et al. 1998. J. Clin. Invest. 101, 2351.
      Sukhova, G.K., et al. 1998. J. Clin. Invest. 102, 576.
      Kirschke, H., and Wiederanders, B. 1994. Methods Enzymol. 244, 500.
      Xin, X.Q., et al. 1992. Arch. Biochem. Biophys. 299, 334.
      Kirschke, H., et al. 1989. Biochem. J. 264, 467.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-VVR-AMC per min at 37°C, pH 6.5. Note: 1 mU = 1 milliunit.
      EC number3.4.22.27
      FormLiquid
      FormulationIn 35 mM potassium phosphate, 35 mM Sodium acetate, 2 mM DTT, 2 mM EDTA, 50% ethylene glycol, pH 6.5.
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by SDS-PAGE
      Specific Activity≥30,000 mU/mg protein
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Harmful
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      219343-25UG 04055977202144

      Documentation

      Cathepsin S, Human, Recombinant, E. coli MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Cathepsin S, Human, Recombinant, E. coli Certificati d'Analisi

      TitoloNumero di lotto
      219343

      Riferimenti bibliografici

      Panoramica delle referenze
      Liuzzo, J.P., et al. 1999. Mol. Med. 5, 334.
      Riese, R.J., et al. 1998. J. Clin. Invest. 101, 2351.
      Sukhova, G.K., et al. 1998. J. Clin. Invest. 102, 576.
      Kirschke, H., and Wiederanders, B. 1994. Methods Enzymol. 244, 500.
      Xin, X.Q., et al. 1992. Arch. Biochem. Biophys. 299, 334.
      Kirschke, H., et al. 1989. Biochem. J. 264, 467.

      Citazioni

      Titolo
    • Ayman Marei, et al. (2005) Superior T cell activation by ESAT-6 as compared with the ESAT-6-CFP-10 complex. International Immunology 17, 1439-1446.
      		•
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-September-2007 RFH
      DescriptionRecombinant, human cathepsin S expressed in E. coli without a tag or fusion protein. A major lysosomal cysteine proteinase that is preferentially expressed in macrophages and microglia. Shown to be involved in the processing of antigenic peptides for presentation by MHC Class II molecules on the surface of antigen-presenting cells by mediating invariant (Ii) chain degradation. Inhibition of cathepsin S results in impaired antigen-presentation.
      FormLiquid
      FormulationIn 35 mM potassium phosphate, 35 mM Sodium acetate, 2 mM DTT, 2 mM EDTA, 50% ethylene glycol, pH 6.5.
      EC number3.4.22.27
      Purity≥90% by SDS-PAGE
      Specific activity≥30,000 mU/mg protein
      Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-VVR-AMC per min at 37°C, pH 6.5. Note: 1 mU = 1 milliunit.
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Harmful
      ReferencesLiuzzo, J.P., et al. 1999. Mol. Med. 5, 334.
      Riese, R.J., et al. 1998. J. Clin. Invest. 101, 2351.
      Sukhova, G.K., et al. 1998. J. Clin. Invest. 102, 576.
      Kirschke, H., and Wiederanders, B. 1994. Methods Enzymol. 244, 500.
      Xin, X.Q., et al. 1992. Arch. Biochem. Biophys. 299, 334.
      Kirschke, H., et al. 1989. Biochem. J. 264, 467.
      Citation
    • Ayman Marei, et al. (2005) Superior T cell activation by ESAT-6 as compared with the ESAT-6-CFP-10 complex. International Immunology 17, 1439-1446.
      		•