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235420 Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem

The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: CPP32/Apopain Inhibitor, Ac-DEVD-CHO

Primary Target: Capase-3, capase-6, capase-7, capase-8, capase-10
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235420
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Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
169332-60-9C₂₀H₃₀N₄O₁₁

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235420-1MG
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      235420-5MG
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          Description
          OverviewA very potent, specific, and reversible inhibitor of caspase-3 (IC50 = 200 pM), caspase-6, caspase-7, caspase-8, and caspase-10.
          Catalogue Number235420
          Brand Family Calbiochem®
          SynonymsCPP32/Apopain Inhibitor, Ac-DEVD-CHO
          References
          ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Nicholson, D.W. 1996. Nature Biotech. 14, 297.
          Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
          Nicholson, D.W., et al. 1995. Nature 376, 37.
          Product Information
          CAS number169332-60-9
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₀H₃₀N₄O₁₁
          Chemical formulaC₂₀H₃₀N₄O₁₁
          ReversibleY
          Sold on the basis of peptide contentY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetCapase-3, capase-6, capase-7, capase-8, capase-10
          Primary Target IC<sub>50</sub>200 pM against caspase-3
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide ContentY
          Peptide SequenceAc-Asp-Glu-Val-Asp-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Numero di catalogo GTIN
          235420-1MG 07790788060220
          235420-5MG 04055977199697

          Documentation

          Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem MSDS

          Titolo

          Scheda di sicurezza (MSDS) 

          Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem Certificati d'Analisi

          TitoloNumero di lotto
          235420

          Riferimenti bibliografici

          Panoramica delle referenze
          Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Nicholson, D.W. 1996. Nature Biotech. 14, 297.
          Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
          Nicholson, D.W., et al. 1995. Nature 376, 37.

          Brochure

          Titolo
          Caspases and other Apoptosis Related Tools Brochure

          Citazioni

          Titolo
        • Qian Zhang and Bibhash C. Paria. (2006) Importance of Uterine Cell Death, Renewal and Their Hormonal Regulation in Hamsters That Show Progesterone-dependent Implantation. Endocrinology 147, 2215-2227.
        • So-Young Park and Adriana Ferreira. (2005) The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which Tau mediates β-amyloid-induced neurodegeneration. Journal of Neuroscience 25, 5365-5375.
        • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.
          		•
          Scheda tecnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-March-2011 RFH
          SynonymsCPP32/Apopain Inhibitor, Ac-DEVD-CHO
          DescriptionA specific and reversible inhibitor of CPP32/Apopain/Yama (IC50 = 0.2 nM). A member of the ICE/CED-3 family of cysteine proteases, which are important in apoptosis.
          FormWhite solid
          CAS number169332-60-9
          Chemical formulaC₂₀H₃₀N₄O₁₁
          Peptide SequenceAc-Asp-Glu-Val-Asp-CHO
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (5 mg/ml) or H₂O
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Nicholson, D.W. 1996. Nature Biotech. 14, 297.
          Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
          Nicholson, D.W., et al. 1995. Nature 376, 37.
          Citation
        • Qian Zhang and Bibhash C. Paria. (2006) Importance of Uterine Cell Death, Renewal and Their Hormonal Regulation in Hamsters That Show Progesterone-dependent Implantation. Endocrinology 147, 2215-2227.
        • So-Young Park and Adriana Ferreira. (2005) The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which Tau mediates β-amyloid-induced neurodegeneration. Journal of Neuroscience 25, 5365-5375.
        • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.
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