Millipore Sigma Vibrant Logo

208902 Calpastatin Peptide - Calbiochem

A 27-amino acid, cell-permeable peptide encoded by exon 1B of human calpastatin that acts as a potent inhibitor of calpain I and calpain II (IC₅₀ = 20 nM for purified rabbit calpain II).

Calpastatin Peptide - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: CS Peptide

Primary Target: calpain 2
View Products on Sigmaaldrich.com
208902
Visualizza prezzi e disponibilità

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₄₂H₂₃₀N₃₆O₄₄S

Prezzi e disponibilità

Numero di catalogo DisponibilitàConfezionamento Qtà/conf Prezzo Quantità
208902-500UG
Verifica della disponibilità in corso...
—
Disponibilità limitata Disponibilità limitata
A magazzino 
Fuori produzione
Disponibili quantità limitate
La disponibilità deve essere confermata
    Prodotti rimanenti: riceverà un nostro avviso
      Prodotti rimanenti: riceverà un nostro avviso
      Will advise
      Contatti il Servizio Clienti
      Contact Customer Service

      		 Bottiglia di vetro 500 μg
      Ricerca del prezzo in corso...
      Non è stato possibile trovare il prezzo
      La quantità minima deve essere un multiplo di
      Maximum Quantity is
      Al termine dell'ordine Maggiori informazioni
      Lei ha salvato ()
       
      —
      Richiedi il prezzo
      		 —
      Description
      OverviewA 27-amino acid, cell-permeable peptide encoded by exon 1B of human calpastatin that acts as a potent inhibitor of calpain I and calpain II (IC50 = 20 nM for purified rabbit calpain II). Does not inhibit either papain or trypsin. Blocks the down-regulation of protein kinase Cε (PKCε) in rat pituitary GH4C1 cells stimulated by thyrotropin-releasing hormone (TRH).
      Catalogue Number208902
      Brand Family Calbiochem®
      SynonymsCS Peptide
      References
      ReferencesEto, A., et al. 1995. J. Biol. Chem. 270, 25115.
      Kawasaki, J., et al. 1989. J. Biochem. 106, 274.
      Maki, M., et al. 1989. J. Biol. Chem. 264, 18866.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₄₂H₂₃₀N₃₆O₄₄S
      Chemical formulaC₁₄₂H₂₃₀N₃₆O₄₄S
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcalpain 2
      Primary Target IC<sub>50</sub>20 nM against calpain II
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceAc-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      208902-500UG 04055977219500

      Documentation

      Calpastatin Peptide - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Calpastatin Peptide - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      208902

      Riferimenti bibliografici

      Panoramica delle referenze
      Eto, A., et al. 1995. J. Biol. Chem. 270, 25115.
      Kawasaki, J., et al. 1989. J. Biochem. 106, 274.
      Maki, M., et al. 1989. J. Biol. Chem. 264, 18866.

      Citazioni

      Titolo
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
      		•
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-May-2008 RFH
      SynonymsCS Peptide
      DescriptionA 27-amino acid, peptide encoded by exon 1B of human calpastatin that acts as a cell-permeable and potent inhibitor of calpain I and calpain II (IC50 = 20 nM for purified rabbit calpain II). Does not inhibit either papain or trypsin. Blocks the down-regulation of protein kinase Cε (PKCε) in rat pituitary GH4C1 cells stimulated by thyrotropin-releasing hormone (TRH).
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Chemical formulaC₁₄₂H₂₃₀N₃₆O₄₄S
      Peptide SequenceAc-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH₂
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml) or 1% Acetic Acid (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesEto, A., et al. 1995. J. Biol. Chem. 270, 25115.
      Kawasaki, J., et al. 1989. J. Biochem. 106, 274.
      Maki, M., et al. 1989. J. Biol. Chem. 264, 18866.
      Citation
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
      		•

      Prodotti e applicazioni correlate

      Related Products

      Numero di catalogo Descrizione  
      208900 Calpastatin, Human, Recombinant, Domain I - Calbiochem Prezzi e disponibilità
      208904 Calpastatin Peptide, Negative Control - Calbiochem Prezzi e disponibilità

      Categorie

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors