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239824 CXCR7 Agonist, VUF11207 - CAS 1378524-41-4 - Calbiochem

CXCR7 Agonist, VUF11207, CAS 1378524-41-4, is a high affinity and high potency ligand of CXCR7 (pKi = 8.1). Induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7.

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Sinonimi: RDC-1 Agonist, GPR159 Agonist, (E)-N-(3-(2-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide, RDC1 agonist, CMKOR1 Agonist, CXCR-7 Agonist, CXC-R7 Agonist

Primary Target: CXCR7
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239824
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CAS #Empirical Formula
1378524-41-4C₂₇H₃₅FN₂O₄

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239824-10MG
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      Description
      OverviewA styrene-amide derivative that acts as a high affinity and high potency ligand of CXCR7 chemokine receptor (pKi = 8.1) and induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7. Exposure of HEK293 T cells transiently transfected with cDNA encoding both CXCR7-RLuc and β-arrestin 2-YFP to VUF11207 is shown to induce a dose-dependent increase in bioluminescence resonance energy transfer (BRET) signal (EC50 = 1.6 nM) indicating its agonist role in β-arrestin2 is recruited to the active receptor.
      Catalogue Number239824
      Brand Family Calbiochem®
      SynonymsRDC-1 Agonist, GPR159 Agonist, (E)-N-(3-(2-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide, RDC1 agonist, CMKOR1 Agonist, CXCR-7 Agonist, CXC-R7 Agonist
      References
      ReferencesWijtmans, M., et al. 2011, Eur J Med Chem 51, 184.
      Product Information
      CAS number1378524-41-4
      FormLight yellow oil
      Hill FormulaC₂₇H₃₅FN₂O₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCXCR7 Agonist, VUF11207, CAS 1378524-41-4, is a high affinity and high potency ligand of CXCR7 (pKi = 8.1). Induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7.
      Biological Information
      Primary TargetCXCR7
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Numero di catalogo GTIN
      239824-10MG 04055977198980