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233105 CL-82198 - CAS 1188890-36-9 - Calbiochem

A selective inhibitor of MMP-13 (IC₅₀ = 10 µM).

CL-82198 - CAS 1188890-36-9 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Primary Target: MMP-13
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233105
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Tabella delle specifiche principali

CAS #Empirical Formula
1188890-36-9C₁₇H₂₂N₂O₃ · HCl

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233105-5MG
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      Description
      OverviewA selective inhibitor of MMP-13 (IC50 = 10 µM). Binds to the S1′ pocket of MMP-13 with its morpholine ring adjacent to the catalytic zinc atom. Does not inhibit MMP-1, MMP-9, and TACE.
      Catalogue Number233105
      Brand Family Calbiochem®
      References
      ReferencesChen, J.M., et al. 2000. J. Am. Chem. Soc. 122, 9648.
      Product Information
      CAS number1188890-36-9
      ATP CompetitiveN
      FormLight yellow solid
      Hill FormulaC₁₇H₂₂N₂O₃ · HCl
      Chemical formulaC₁₇H₂₂N₂O₃ · HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMMP-13
      Primary Target IC<sub>50</sub>10 µM against MMP-13
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      233105-5MG 04055977217629

      Documentation

      CL-82198 - CAS 1188890-36-9 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      CL-82198 - CAS 1188890-36-9 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      233105

      Riferimenti bibliografici

      Panoramica delle referenze
      Chen, J.M., et al. 2000. J. Am. Chem. Soc. 122, 9648.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      DescriptionA selective inhibitor of MMP-13 (IC50 = 10 µM) that does not appear to act by chelating Zn2+. Binds within the entire S1' pocket of MMP-13, docking with the morpholine ring adjacent to the catalytic zinc atom. Does not inhibit MMP-1, MMP-9, and TACE.
      FormLight yellow solid
      CAS number1188890-36-9
      Chemical formulaC₁₇H₂₂N₂O₃ · HCl
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityH₂O (25 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesChen, J.M., et al. 2000. J. Am. Chem. Soc. 122, 9648.