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420358 CBFβ Activator, Kartogenin - CAS 4727-31-5 - Calbiochem

The CBFβ Activator, Kartogenin modulates the biological activity of CBFβ. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 2-(Biphenyl-4-ylcarbamoyl)benzoic acid

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420358
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Tabella delle specifiche principali

CAS #Empirical Formula
4727-31-5C₂₀H₁₅NO₃

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420358-25MG
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      Description
      OverviewA cell-permeable biphenylcarbamoylbenzoate compound that potently induces the differentiation of human mesenchymal stem cells (hMSCs) into chondrocytes (EC50 = 100 nM). Reversibly binds to the FC-1 fragment of filamin A and disrupts its association with CBFβ leading to nuclear localization of CBFβ and binding to runt-related transcription factor (RUNX) to regulate chondrogenesis. Also reported to inhibit cytokine-induced release of nitric oxide (NO) and glycosaminoglycan (GAG). Exhibits chondroprotective properties and promotes cartilage repair in murine osteoarthritis models. Shown to up-regulate the levels of TIMP1, collagen, and aggrecan thereby blocking further matrix breakdown without affecting the activities of MMP-3, MMP-13, and aggrecanase in primary chondrocytes or hMSCs.
      Catalogue Number420358
      Brand Family Calbiochem®
      Synonyms2-(Biphenyl-4-ylcarbamoyl)benzoic acid
      References
      ReferencesJohnson, K., et al. 2012. Science 336, 717.
      Product Information
      CAS number4727-31-5
      FormWhite solid
      Hill FormulaC₂₀H₁₅NO₃
      Chemical formulaC₂₀H₁₅NO₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      420358-25MG 04055977187540

      Documentation

      CBFβ Activator, Kartogenin - CAS 4727-31-5 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      CBFβ Activator, Kartogenin - CAS 4727-31-5 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      420358

      Riferimenti bibliografici

      Panoramica delle referenze
      Johnson, K., et al. 2012. Science 336, 717.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-July-2012 JSW
      Synonyms2-(Biphenyl-4-ylcarbamoyl)benzoic acid
      DescriptionA cell-permeable biphenylcarbamoylbenzoate compound that potently induces the differentiation of human mesenchymal stem cells (hMSCs) into chondrocytes (EC50 = 100 nM). Reversibly binds to the FC-1 fragment of filamin A and disrupts its association with CBFβ leading to nuclear localization of CBFβ and binding to runt-related transcription factor (RUNX) to regulate chondrogenesis. Also reported to inhibit cytokine-induced release of nitric oxide (NO) and glycosaminoglycan (GAG). Exhibits chondroprotective properties and promotes cartilage repair in murine osteoarthritis models. Shown to up-regulate the levels of TIMP1, collagen, and aggrecan thereby blocking further matrix breakdown without affecting the activities of MMP-3, MMP-13, and aggrecanase in primary chondrocytes or hMSCs.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number4727-31-5
      Chemical formulaC₂₀H₁₅NO₃
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJohnson, K., et al. 2012. Science 336, 717.