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205531 CA-074 Me - Calbiochem

CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B.

CA-074 Me - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Cathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester

Primary Target: cathepsin B
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205531
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Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₉H₃₁N₃O₆

Prezzi e disponibilità

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205531-1MG
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      Description
      OverviewA cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
      Catalogue Number205531
      Brand Family Calbiochem®
      SynonymsCathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
      References
      ReferencesSever, N., et al. 2002. Biol. Chem. 383, 839.
      Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
      Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
      Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₉H₃₁N₃O₆
      Chemical formulaC₁₉H₃₁N₃O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcathepsin B
      Primary Target IC<sub>50</sub>2.24 nM against cathepsin B
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      205531-1MG 07790788048433

      Documentation

      CA-074 Me - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      CA-074 Me - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      205531

      Riferimenti bibliografici

      Panoramica delle referenze
      Sever, N., et al. 2002. Biol. Chem. 383, 839.
      Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
      Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
      Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.

      Citazioni

      Titolo
      IM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-May-2008 RFH
      SynonymsCathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
      DescriptionA cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B.
      FormWhite solid
      Chemical formulaC₁₉H₃₁N₃O₆
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSever, N., et al. 2002. Biol. Chem. 383, 839.
      Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
      Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
      Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
      CitationIM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.