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SCT053 BioTracker™ SiRNO (Nitric Oxide)- Near Infrared Live Cell Dye

Live cell imaging dye for cellular nitric oxide (NO) localized to mitochondria and lysosome, used as an indicator of host defense, homeostasis and developmental functions.

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SCT053
1 mg  
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      Replacement Information
      Description
      Catalogue NumberSCT053
      DescriptionBioTracker™ SiRNO (Nitric Oxide)- Near Infrared Live Cell Dye
      OverviewNitric oxide (No) is a reactive nitrogen species which is produced by nitric oxide synthase (NOS). NO is involved in many physiological processes including regulation of blood pressure, homeostasis, activation of immune system, neural communication, contraction of both smooth muscle and vascular tissue. Therefore, detection and quantification of NO is critical to understanding health and disease.

      The BioTracker™ SiRNO-Nitric oxide dye is a live cell near-infrared fluorescent imaging probe for detecting nitric oxide (NO). The probe targets NO specifically in the mitochondria and lysosome of living cells. The probe shows no cross reactivity to a variety of biomolecules and other reactive species including: ascorbic acid (AA), dehydroascorbic acid (DHA), methylglyoxal (MGO), GSH, Cys, Hcy, H2O2, ClO−, -OH, O2−, NO2−, and ONOO−. The SiRNO dye is pH insensitive in the range of 5.5 - 8.0, showing that it is suitable for physiological pH range. The SiRNO dye has been successfully used to detect NO in live cells, animal tissue and in vivo experiments.

      Spectral Properties
      Absorbance: 633nm
      Emission: 650-750nm

      References
      Mao Z et al. Development of a Silicon-Rhodamine Based Near-Infrared Emissive Two-Photon Fluorescent Probe for Nitric Oxide. Anal Chem. 2017 Sep19;89(18):9620-9624
      Alternate Names
      • Live cell imaging probe
      References
      Product Information
      Detection methodFluorescence
      PresentationLyophilized
      Applications
      ApplicationLive cell imaging dye for cellular nitric oxide (NO) localized to mitochondria and lysosome, used as an indicator of host defense, homeostasis and developmental functions.
      Key Applications
      • Cell Based Assays
      Application NotesLive cell fluorescent imaging
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity: ≥ 98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
      Molar Mass: 758.34 g/mol
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore BioTracker SiRNO-Nitric Oxide Live Cell Dye at -20°C, desiccate and protect from light
      Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      SCT053 04054839736339