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SCT091 BioTracker NIR-HO Live Cell Dye

Near-Infrared probe for imaging Hg2+-and ONOO− in mercury-induced oxidative stress studies.

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SCT091
1 mg  
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      Replacement Information
      Description
      Catalogue NumberSCT091
      DescriptionBioTracker NIR-HO Live Cell Dye
      OverviewMercury (Hg) is considered an extremely toxic heavy metal which is extremely harmful to human health. Researchers are investigating the role of Hg2+-induced oxidative stress, via peroxynitrite (ONOO−) level upregulation, in the pathogenic mechanisms of mercury toxicity.

      BioTracker NIR-HO Live Cell Dye is a near-infrared (NIR) fluorescent probe for the detection and visualization of Hg2+-induced ONOO− generation in vitro and in vivo. This fluorescent probe was designed with a “dual-key-and-lock” strategy where emission can only be switched on in the presence of both Hg2+ and ONOO− (1). It provides an effective method for detecting and imaging Hg2+ and ONOO- in oxidative stress studies and in the development of detoxifying drugs.

      Spectral Properties
      Excitation: 550 nm
      Emission: 680 nm

      Reference:
      1. Yang, Xiaopeng, et al. "Imaging Hg2+-induced oxidative stress by NIR molecular probe with “dual-key-and-lock” strategy." Analytical Chemistry 92.17 (2020): 12002-12009.
      Alternate Names
      • Live Cell Imaging Probe
      References
      Product Information
      Detection methodFluorescence
      PresentationLyophilized. Yellow solid.
      Applications
      ApplicationNear-Infrared probe for imaging Hg2+-and ONOO− in mercury-induced oxidative stress studies.
      Biological Information
      Molecular Weight506.6
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C, desiccate and protect from light.
      Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      SCT091 04065265944496