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SCT073 BioTracker NIR Amyloid-ß Plaque Imaging Dye

Near-Infrared probe for live cell imaging of amyloid-ß (Aß) plaques, critical for the early detection of Alzheimer's disease.

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SCT073
1 mg  
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      Replacement Information
      Description
      Catalogue NumberSCT073
      DescriptionBioTracker NIR Amyloid-ß Plaque Imaging Dye
      OverviewAlzheimer's disease (AD) is a progressive neurodegenerative brain disorder and does not have a proper cure yet. The formation and accumulation of amyloid-ß (Aß) plaques in the brain is thought to be a critical pathological hallmark for early diagnosis of AD. Current gold standard probes for histological staining of amyloid fibrils, such as thioflavin derivatives, have several drawbacks. These probes suffer from noises from always-on pattern, limited blood-brain-barrier (BBB) penetration and distorted signals.

      BioTracker NIR Amyloid-ß Plaque Imaging Dye is aggregation-induced-emission (AIE) active probe that can be used to detect amyloid-ß plaques in vivo as well as ex-vivo. This probe has been tested in mouse models of AD, as well as ex-vivo brain tissue sections. The BioTracker probe possess excellent features, such as: (1) ultrahigh signal-to-noise (S/N) ratio with integrating background minimization and fidelity signal amplification, (2) remarkable binding affinity to Aß plaques with efficient BBB penetrability, and (3) NIR AIE-active emission with excellent photostability.

      Spectral Properties
      Absorbance: 500 nm
      Emission: 720 nm

      References
      Fu W, et al. Rational Design of Near-Infrared Aggregation-Induced-Emission Active Probes: In Situ Mapping of Amyloid-ß Plaques with Ultrasensitivity and High-Fidelity. J. Am. Chem. Soc. 2019, 141, 3171-3177.
      Alternate Names
      • Live Cell Imaging Probe
      References
      Product Information
      Detection methodFluorescence
      PresentationLyophilized. Dark red solid.
      Applications
      ApplicationNear-Infrared probe for live cell imaging of amyloid-ß (Aß) plaques, critical for the early detection of Alzheimer's disease.
      Key Applications
      • Cell Based Assays
      • Immunocytochemistry
      • Immunohistochemistry
      • Neuroscience
      Application NotesLive cell fluorescent imaging
      Biological Information
      Molecular Weight564.7
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity ≥ 97% confirmed by HPLC, HNMR, LC-MS, and elemental analysis.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore BioTracker NIR Amyloid-b Imaging Dye at -20 oC, dessicate and protect from light.
      Note: Centrifuge vial briefly to collect conents at bottom of vial before opening.
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      SCT073 04061842297535