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196322 Baicalein - CAS 491-67-8 - Calbiochem

A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC₅₀= 120 nM) and reverse transcriptase.

Baicalein - CAS 491-67-8 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 5,6,7-Trihydroxyflavone

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196322
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196322-10MG
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      Description
      OverviewA cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC50 = 120 nM) and reverse transcriptase. Protects cortical neurons from β-amyloid induced toxicity. Reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Also inhibits cellular Ca2+ uptake and mobilization, and adjuvant-induced arthritis. Reported to inhibit microsomal lipid peroxidation by forming an iron-baicalein complex. Inhibits topoisomerase II and induces cell death in hepatocellular carcinoma cell lines. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated protein kinase C.
      Catalogue Number196322
      Brand Family Calbiochem®
      Synonyms5,6,7-Trihydroxyflavone
      References
      ReferencesLeabeau, A., et al. 2001. Neuroreport 12, 2199.
      Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.
      Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.
      Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.
      Butenko, I.G., et al. 1993. Agents Actions 39, C49.
      Abe, K., et al. 1990. Chem. Pharm. Bull. 38, 209.
      Kimura, Y., et al. 1987. Biochim. Biophys. Acta 922, 278.
      Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun. 105, 1090.
      Product Information
      CAS number491-67-8
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₅H₁₀O₅
      Chemical formulaC₁₅H₁₀O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target12-lipoxygenase
      Primary Target IC<sub>50</sub>120 nM against 12-lipoxygenase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      196322-10MG 04055977206463

      Documentation

      Baicalein - CAS 491-67-8 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Baicalein - CAS 491-67-8 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      196322

      Riferimenti bibliografici

      Panoramica delle referenze
      Leabeau, A., et al. 2001. Neuroreport 12, 2199.
      Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.
      Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.
      Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.
      Butenko, I.G., et al. 1993. Agents Actions 39, C49.
      Abe, K., et al. 1990. Chem. Pharm. Bull. 38, 209.
      Kimura, Y., et al. 1987. Biochim. Biophys. Acta 922, 278.
      Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun. 105, 1090.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-August-2018 JSW
      Synonyms5,6,7-Trihydroxyflavone
      DescriptionA cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC50 = 120 nM) and reverse transcriptase. Reduces leukotriene biosynthesis and the release of lysosomal enzymes. Also inhibits cellular Ca2+ uptake and mobilization, and adjuvant-induces arthritis. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated PKC.
      FormYellow solid
      CAS number491-67-8
      Chemical formulaC₁₅H₁₀O₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (20 mg/ml) or Acetone
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Irritant
      Merck USA index14, 942
      ReferencesLeabeau, A., et al. 2001. Neuroreport 12, 2199.
      Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.
      Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.
      Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.
      Butenko, I.G., et al. 1993. Agents Actions 39, C49.
      Abe, K., et al. 1990. Chem. Pharm. Bull. 38, 209.
      Kimura, Y., et al. 1987. Biochim. Biophys. Acta 922, 278.
      Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun. 105, 1090.