533169 Sigma-AldrichBET Inhibitor, I-BET726 - CAS 1300031-52-0 - Calbiochem
BET Inhibitor, I-BET726, is a cell-permeable, potent, and selective inhibitor of BET family proteins (IC₅₀ = 41, 31, and 22 nM for BRD2, BRD3, BRD4, respectively).
More>> BET Inhibitor, I-BET726, is a cell-permeable, potent, and selective inhibitor of BET family proteins (IC₅₀ = 41, 31, and 22 nM for BRD2, BRD3, BRD4, respectively). Less<<Sinonimi: BET Inhibitor, BET726, GSK1324726A, 4-((2S,4R)-1-Acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid
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Panoramica
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Tabella delle specifiche principali
CAS # | Empirical Formula |
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1300031-52-0 | C₂₅H₂₃ClN₂O₃ |
Prezzi e disponibilità
Numero di catalogo | Disponibilità | Confezionamento | Qtà/conf | Prezzo | Quantità | |
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5331690001 |
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Bottiglia di vetro | 5 mg |
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References | |
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References | Gosmini, R., et al. 2014. J. Med. Chem. 57, 811. Wyce, A., et al. 2013. Plos One. 8, e72967. |
Product Information | |
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CAS number | 1300031-52-0 |
Form | Light yellow solid |
Hill Formula | C₂₅H₂₃ClN₂O₃ |
Chemical formula | C₂₅H₂₃ClN₂O₃ |
Reversible | Y |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | BET |
Primary Target IC<sub>50</sub> | 41 nM, 31 nM, and 22 nM for BRD2, BRD3, BRD4, BRDT respectively |
Primary Target K<sub>i</sub> | 4.4 nM for BRD4 |
Purity | ≥98% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Dimensions |
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Materials Information |
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Safety Information according to GHS |
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Product Usage Statements |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
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Supplemental Information |
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Specifications |
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Global Trade Item Number | |
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Numero di catalogo | GTIN |
5331690001 | 04055977281491 |
Documentation
BET Inhibitor, I-BET726 - CAS 1300031-52-0 - Calbiochem MSDS
Titolo |
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Riferimenti bibliografici
Panoramica delle referenze |
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Gosmini, R., et al. 2014. J. Med. Chem. 57, 811. Wyce, A., et al. 2013. Plos One. 8, e72967. |