Millipore Sigma Vibrant Logo

MABN110 Anti-pro-BDNF Antibody, clone 5D4.1

This Anti-pro-BDNF Antibody, clone 5D4.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of pro-BDNF.

Anti-pro-BDNF Antibody, clone 5D4.1: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: BDNF UniProt Number: P23560
View Products on Sigmaaldrich.com
MABN110
100 µg  
Ricerca del prezzo in corso...
Non è stato possibile trovare il prezzo
La quantità minima deve essere un multiplo di
Maximum Quantity is
Al termine dell'ordine Maggiori informazioni
Lei ha salvato ()
 
—
Richiedi il prezzo
—
Disponibilità limitata Disponibilità limitata
A magazzino 
Fuori produzione
Disponibili quantità limitate
La disponibilità deve essere confermata
    Prodotti rimanenti: riceverà un nostro avviso
      Prodotti rimanenti: riceverà un nostro avviso
      Will advise
      Contatti il Servizio Clienti
      Contact Customer Service

      Offerte speciali

       

      Contatti il Servizio Clienti

      Panoramica

      Replacement Information

      Offerte speciali

      100% Performance Guaranteed

      Tabella delle specifiche principali

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN110
      DescriptionAnti-pro-BDNF Antibody, clone 5D4.1
      Alternate Names
      • Brain-derived neurotrophic factor
      • Abrineurin
      Background InformationBrain Derived Neurotrophic Factor (BDNF) is a secreted protein that promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer’s and Huntington disease patients. BDNF may play a role in the regulation of stress response and in the biology of mood disorders. BDNF exists as monomers or homodimers and binds to TRKB/NTRK2 receptors.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-pro-BDNF Antibody, clone 5D4.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of pro-BDNF.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern Blotting Analysis: A 0.5 µg/mL dilution from a representative lot detected 10 µg of recombinant protein Pro-BDNF but not recombinant protein BDNF.
      Immunohistochemistry Analysis: A 1:2000 dilution from a representative lot detected Pro-BDNF in human cerebral cortex and thalamic tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to Human pro-BDNF.
      Clone5D4.1
      Concentration1 mg/mL
      HostMouse
      SpecificityThe antibody reacts to the pro form of BDNF
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • BDNF
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~ 34 kDa observed (Neurochemical Journal, 2012, Vol. 6, No. 4, pp 260-264).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Rat Brain cell lysate.

      Western Blotting Analysis: A 0.5 µg/mL diultion of this antibody detected pro-BDNF in 200 µg of Rat Brain cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      MABN110 04055977112719

      Prodotti e applicazioni correlate

      Related Products

      Numero di catalogo Descrizione  
      AB1513 Anti-Brain Derived Neurotrophic Factor Antibody Prezzi e disponibilità
      AB1513P Anti-Brain Derived Neurotrophic Factor Antibody Prezzi e disponibilità
      AB1534 Anti-Brain Derived Neurotrophic Factor Antibody Prezzi e disponibilità
      AB1534SP Anti-Brain Derived Neurotrophic Factor Antibody Prezzi e disponibilità
      AB1779 Anti-Brain Derived Neurotrophic Factor Antibody Prezzi e disponibilità
      AB1779SP Anti-Brain Derived Neurotrophic Factor Antibody Prezzi e disponibilità
      AB5613 Anti-Brain Derived Neurotrophic Factor Antibody, pro Prezzi e disponibilità
      AB5613P Anti-Brain Derived Neurotrophic Factor Antibody, pro Prezzi e disponibilità
      AB9042 Anti-Brain Derived Neurotrophic Factor Antibody, pro Prezzi e disponibilità
      AB9612 Anti-Brain Derived Neurotrophic Factor Antibody Prezzi e disponibilità
      Show more

      Categorie

      Life Science Research > Antibodies and Assays > Primary Antibodies