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ABE1062 Anti-monomethyl Histone H2A.Z Antibody (Lys 7)

Anti-monomethyl Histone H2A.Z (Lys 7) is an antibody against monomethyl Histone H2A.Z (Lys 7) for use in WB, ICC, DB, IP.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: H2AFZ, H2AZ UniProt Number: P0C0S5
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ABE1062
100 µg  
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      Tabella delle specifiche principali

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICC, DB, IPRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1062
      DescriptionAnti-monomethyl Histone H2A.Z Antibody (Lys 7)
      Alternate Names
      • Histone H2A.Z
      • H2A/z
      Background InformationH2A.Z, also known as H2AFZ, is a variant of histone H2A that is highly conserved from yeast to humans. Like other histone variants, H2A.Z is encoded by a unique gene, resulting in a slightly divergent type of H2A with specialized functions. H2A.Z is involved in chromatin compaction by stabilizing the histone octamer within the nucleosome. It promotes gene expression through the creation of an open domain of chromatin that is more easily transcribed. H2A.Z is nonrandomly distributed throughout the genome, targeted primarily to pericentric heterochromatin, but excluded from the inactive X chromosome and the nucleolus. H2A.Z is associated with both euchromatin and facultative heterochromatin. DNA methylation can influence chromatin structure and effect gene silencing by excluding H2A.Z, and likewise, H2A.Z protects genes from DNA methylation. Thus, H2A.Z plays a role in regulating heterochromatin silencing and is involved in transcriptional control.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-monomethyl Histone H2A.Z (Lys 7) is an antibody against monomethyl Histone H2A.Z (Lys 7) for use in WB, ICC, DB, IP.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Dot Blot
      • Immunoprecipitation
      Application NotesImmunocytochemistry Analysis: A 1:2,000 dilution from a representative lot detected monomethyl Histone H2A.Z (Lys 7) in HeLa and NIH/3T3 cells.
      Dot Blot Analysis: A 1:1,000 dilution from a representative lot detected monomethyl Histone H2A.Z (Lys 7) in Histone peptides with various modifications.
      Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated monomethyl Histone H2A.Z (Lys 7) in 500 µg of HeLa acid extract.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human monomethyl Histone H2A.Z (Lys 7) near the N-terminal.
      EpitopeNear N-terminal
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • H2AFZ
      • H2AZ
      Modifications
      • Methylation
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~16 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa acid extract.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected monomethyl Histone H2A.Z (Lys 7) in 10 µg of HeLa acid extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      ABE1062 04055977115871

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      Categorie

      Life Science Research > Antibodies and Assays > Primary Antibodies