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MABE1055-25UL Anti-RecQ1 Antibody, clone 5A12.1

Anti-RecQ1, clone 5A12.1, Cat. No. MABE1055, is a highly specific mouse monoclonal antibody that targets RecQ1 and has been tested for use in Western Blotting and Immunohistochemistry (Paraffin).

Anti-RecQ1 Antibody, clone 5A12.1: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Epigenetics & Nuclear Function Gene Symbol: RECQL, RECQ1, RECQL1 UniProt Number: P46063
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MABE1055-25UL
25 µL  
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      Tabella delle specifiche principali

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE1055-25UL
      DescriptionAnti-RecQ1 Antibody, clone 5A12.1
      Alternate Names
      • ATP-dependent DNA helicase Q1
      • EC:3.6.4.12
      • DNA helicase
      • RecQ-like type 1
      • RecQ1
      • DNA-dependent ATPase Q1
      • RecQ protein-like 1
      Background InformationATP-dependent DNA helicase Q1 (UniProt: P46063; also known as EC:3.6.4.12, DNA helicase, RecQ-like type 1, RecQ1, DNA-dependent ATPase Q1, RecQ protein-like 1) is encoded by the RECQL (also known as RECQ1, RECQL1) gene (Gene ID: 5965) in human. RecQ helicases are a ubiquitous family of DNA unwinding enzymes involved in the maintenance of chromosome stability. They participate in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. Five members of the RecQ family have been reported in human cells: BLM, RECQ1, RECQ4, RECQ5, and WRN. RecQ1 displays high expression in heart, lung, skeletal muscle and kidney. It is also highly expressed in tumor cells and although brain exhibits low level of EecQ1, its expression is dramatically increased in human glioblastoma. Depletion of RecQ1 affects proliferation of glioblastoma cells and causes an increase in the level of DNA damage. RecQ1 depleted tumor cells are shown to be more sensitive to anti-tumor agents, such as hydroxyurea and temozolomide.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-RecQ1, clone 5A12.1, Cat. No. MABE1055, is a highly specific mouse monoclonal antibody that targets RecQ1 and has been tested for use in Western Blotting and Immunohistochemistry (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry (Paraffin) Analysis: A 1:50-250 dilution from a representative lot detected RecQ1 in human kidney and human tonsil tissue sections.
      Biological Information
      ImmunogenGST/His-tagged recombinant fragment corresponding to 87 amino acids from the internal region of human ATP-dependent DNA helicase Q1.
      Clone5A12.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 5A12.1 specifically detects human ATP-dependent DNA helicase Q1 (RecQ1). It targets an epitope within 87 amino acids from the internal region.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RECQL
      • RECQ1
      • RECQL1
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~73 kDa observed; 73.46 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Raji cell lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected RecQ1 in Raji cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      MABE1055-25UL 04054839510274