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MABC1032 Anti-Pro-Atrial Natriuretic Peptide Antibody, clone 11E3.9

This Anti-Pro-Atrial Natriuretic Peptide Antibody, clone 11E3.9 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Pro-Atrial Natriuretic Peptide.

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Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: NPPA, ANP, PND UniProt Number: P01160
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MABC1032
100 μg  
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      Tabella delle specifiche principali

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, HWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC1032
      DescriptionAnti-Pro-Atrial Natriuretic Peptide Antibody, clone 11E3.9
      Alternate Names
      • CDD-ANF
      • Pro-Atrial Natriuretic Peptide
      • Natriuretic peptides A
      • Cardiodilatin
      • CDD
      • Cardiodilatin-related peptide
      • CDP
      • Prepronatriodilatin
      Background InformationNatriuretic peptides A (UniProt P01160; also known as Atriopeptin, Cardiodilatin, Cardiodilatin-related peptide, Cardionatrin, CDD, CDD-ANF, CDP, Natriuretic peptide precursor A, Prepronatriodilatin) is encoded by the NPPA (also known as ANF, ANP, ATFB6, ATRST2, PND) gene (Gene ID 4878) in human. Atrial natriuretic peptide (ANP), also called atrial natriuretic factor, is a cardiac hormone that reduces high blood pressure by promoting salt excretion, decreasing blood volume, and relaxing vessel tension in a receptor-dependent manner. Deficiency in either ANP or its receptor causes spontaneous hypertension in knockout mice. ANP is initially synthesized in cardiac myocytes as a 153 a.a. precursor with a signal (a.a.1-25) and a propeptide (a.a. 26-123) sequence. The removal of the signal peptide yields pro-ANP (a.a. 26-151), which is further cleaved by the transmembrane cardiac serine protease Corin to yield mature ANP (a.a. 124-151), also known as atrial natriuretic factor (ANF). ANP is a short-lived molecule partly due to its proteolytic degradation by the kidney Neprilysin, also known as neutral endopeptidase 24.11.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Pro-Atrial Natriuretic Peptide Antibody, clone 11E3.9 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Pro-Atrial Natriuretic Peptide.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected human Pro-Atrial Natriuretic Peptide in 10 µg of human heart tissue lysate.
      Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected human Pro-Atrial Natriuretic Peptide in rat cardiac myocytes.
      Biological Information
      ImmunogenHis-tagged recombinant protein corresponding to human Pro-Atrial Natriuretic Peptide.
      EpitopePropeptide (a.a. 26-123)
      Clone11E3.9
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityExpected to react with both prepro- and pro-atrial natriuretic peptide (ANP), but not mature ANP (a.a. 124-151 of prepro sequence).
      IsotypeIgG1κ
      Species Reactivity
      • Rat
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NPPA
      • ANP
      • PND
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~17 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat heart tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected human Pro-Atrial Natriuretic Peptide protein in 10 µg of rat heart tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      MABC1032 04055977288292

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      Categorie

      Life Science Research > Antibodies and Assays > Primary Antibodies