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AB5675-AF488 Anti-Metabotropic Glutamate Receptor 5 Antibody, Alexa Fluor® 488

Anti-Metabotropic Glutamate Receptor 5 Antibody, Alexa Fluor® 488 is an antibody against Metabotropic Glutamate Receptor 5 for use in Immunocytochemistry, Immunofluorescence.

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Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: Grm5, Gprc1e, Mglur5 UniProt Number: Q3UVX5
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AB5675-AF488
100 µL  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RICC, IFRbAlexaFluor®488Polyclonal Antibody
      Description
      Catalogue NumberAB5675-AF488
      DescriptionAnti-Metabotropic Glutamate Receptor 5 Antibody, Alexa Fluor® 488
      Alternate Names
      • Metabotropic glutamate receptor 5
      • mGluR5
      • G protein-coupled receptor GRM5
      • G protein coupled receptor family C, group 1, member E
      Background InformationMetabotropic glutamate receptor 5 or mGluR5 (UniProt P31424; also known as G protein-coupled receptor GRM5, G protein coupled receptor family C, group 1, member E) is encoded by the Grm5 (also known as Gprc1e, Mglur5) gene (Gene ID 24418) in rat species. The metabotropic glutamate receptors belong to a family of G protein-coupled receptors that have been divided into 3 groups based on their sequence homology, putative signal transduction mechanisms, and pharmacologic properties. mGluR1 and mGluR5 constitute Group I metabotropic glutamate receptors. mGluR5 is found on postsynaptic terminals of neurons and microglia. mGluR5 signals via Gq/G11 coupling to activate phospholipase C, resulting in calcium mobilization and activation of protein kinase C (PKC). In addition, mGluR5 is also reported to mediate signaling involving Src-family protein tyrosine kinase in a G protein-independent manner.
      References
      Product Information
      FormatAlexaFluor®488
      PresentationPurified rabbit polyclonal antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Metabotropic Glutamate Receptor 5 Antibody, Alexa Fluor® 488 is an antibody against Metabotropic Glutamate Receptor 5 for use in Immunocytochemistry, Immunofluorescence.
      Key Applications
      • Immunocytochemistry
      • Immunofluorescence
      Application NotesImmunocytochemistry Analysis: An 1:100 dilution from a representative lot detected Metabotropic Glutamate Receptor 5 in rat cortical neurons.
      The unconjugated antibody (Cat. No. AB5675) is shown to be suitable also for Western blotting and immunohistochemistry applications.
      Biological Information
      ImmunogenSynthetic peptide corresponding to a sequence from the C-terminal cytoplasmic domain of rat mGluR5.
      EpitopeC-terminal cyoplasmic domain.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityExpected to react with all spliced isoforms of human, rat, and mouse mGluR5 reported by UniProt (P41594, P31424 and Q3UVX5, respectively).
      Species Reactivity
      • Rat
      Species Reactivity NoteRat. Predicted to react with Mouse, Human, Bovine, Primate, Feline, Horse based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Grm5
      • Gprc1e
      • Mglur5
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~150 kDa observed.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunofluorescence in rat brain tissue sections.

      Immunofluorescence Analysis: An 1:100 dilution of this antibody detected Metabotropic Glutamate Receptor 5 in rat cerebellum and rat brain tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      AB5675-AF488 04055977329230

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      Categorie

      Life Science Research > Antibodies and Assays > Primary Antibodies